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Synthesis 1989; 1989(10): 783-784
DOI: 10.1055/s-1989-27396
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Direct Vilsmeier-Haack Chloroacetylation of Pyrroles

Piero Dalla Croce* , Concetta La Rosa, Alberto Ritieni
  • *Dipartimento di Chimica Organica e Industriale, Centro CNR, Via Venezian 21, I-20133 Milano, Italy
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Publication Date:
02 May 2002 (online)

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Reaction of pyrroles with N,N-dimethyl-2-chloroacetamide in the presence of phosphorus oxychloride leads to a mixture of 2- and 3-chloroacetylpyrroles, which can be separated by chromatography.

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