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Synthesis 1989; 1989(6): 451-452
DOI: 10.1055/s-1989-27285
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Simple and Efficient Copper-Catalyzed One-Pot Conversion of Aldehydes into Nitriles

Patrice Capdevielle* , André Lavigne, Michel Maumy
  • *Laboratoire de Recherches Organiques de l'ESPCI, associé au CNRS, 10 rue Vauquelin, F-75231 Paris Cedex 05, France
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Publication History

Publication Date:
17 September 2002 (online)

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Aromatic, heterocyclic, and tertiary aliphatic nitriles are prepared from the corresponding aldehydes by the ammonium chloride/copper powder/oxygen system in pyridine. This new one-flask procedure affords very high to quantitative yields of pure nitriles.

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