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Synthesis 1989; 1989(5): 381-382
DOI: 10.1055/s-1989-27257
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A Novel Route to 6-Perfluoroalkyluracils

Hidemitsu Uno* , Tetsuya Terakawa, Hitomi Suzuki
  • *Advanced Instrumentation Center for Chemical Analysis, Department of Chemistry, Faculty of Science, Ehime University, Bunkyo-cho 2-5, Matsuyama 790, Japan
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Publication History

Publication Date:
17 September 2002 (online)

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Perfluoroalkyllithiums generated in situ from perfluoroalkyl iodides and methyllithium add to 2,4-dichloropyrimidines in the presence of boron trifluoride etherate to give 4-perfluoroalkyl-3,4-dihydropyrimidines, which are converted to 6-perfluoroalkyl-5,6-dihydrouracils on hydrolysis, and to 6-perfluoroalkyluracils by oxidation with dichlorodicyano-1,4-benzoquinone (DDQ) followed by hydrolysis.

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