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Synthesis 1988; 1988(6): 475
DOI: 10.1055/s-1988-27611
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A Facile Synthesis of (S)-Isoserine from (S)-Malic Acid

Maria J. Milewska* , Tadeusz Połoński
  • *Department of Organic Chemistry, Technical University of Gdańsk, PL-80-952 Gdańsk, Poland
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Publication Date:
20 August 2002 (online)

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(S)-Malic acid is converted into 4-oxo-1,3-dioxolan-5-acetic acid. The carboxy group is transformed into an amino group via Curtius reaction and the dioxolanone moiety is hydrolytically cleaved to afford (S)isoserine.

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