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Synthesis 1988; 1988(5): 379-381
DOI: 10.1055/s-1988-27580
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Synthesis of 1,1-Diaryl-2,2-dimethoxyethanes

Michael S. Ashwood* , Lawrence A. Bell, Peter G. Houghton, Stanley H. B. Wright
  • *Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, England
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Publication Date:
20 August 2002 (online)

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The 1,4-additon of Grignard reagents to ß-nitrostyrene to give 1,1-diaryl-2-nitroethanes and their subsequent conversion via a modified Nef reaction into 1,1-diaryl-2,2-dimethoxyethanes (diarylacetaldehyde dimethyl acetals) is described. The scope of the reaction has been briefly explored and one example demonstrated on a large scale.

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