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Synthesis 1988; 1988(4): 316-318
DOI: 10.1055/s-1988-27553
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Dimetalation of Furans and Thiophenes. One-Pot Procedures for Furan-2,5- and Thiophene-2,5-dicarboxaldehyde

Ben L. Feringa* , Ron Hulst, Ruud Rikers, Lambert Brandsma
  • *Department of Organic Chemistry, University of Groningen, Nijenborgh 16, NL-9747 AG Groningen, The Netherlands
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Publication Date:
20 August 2002 (online)

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A new one-pot synthesis of furan-2,5-dicarboxaldehyde and thiophene-2, 5-dicarboxaldehyde in 80% and 75% yields, respectively, via dimetalation of furan and thiophene, is described. In addition, monoprotected furan-2,5-dicarboxaldehyde was prepared in 73% yield from furfural.

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