Synthesis 1987; 1987(3): 260-262
DOI: 10.1055/s-1987-27908
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Verbesserte Synthese von 7,7-Difluorcyclopropabenzol

C. Glück* , V. Poignée, H. Schwager
  • *Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 364, D-6900 Heidelberg, West Germany
Further Information

Publication History

Publication Date:
12 September 2002 (online)

Improved Synthesis of 7,7-Difluorocyclopropabenzene A five-step, optimised sequence for the preparation of the title compound is reported. Trichloroethylene is converted to 1,6-dichloro-7,7-difluorobicyclo[4.1.0]hept-3-ene (5) via pentachlorocyclopropane, tetrachlorocyclopropene, and 1,2-dichloro-3,3-difluorocyclopropene by modifications of the procedures reported by Tobey and coworkers. Final dehydrochlorination of 5 allows the production of 7,7-difluorocyclopropabenzene in 50 g quantities.