Download PDF
Synthesis 1986; 1986(12): 1044-1045
DOI: 10.1055/s-1986-31868
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

One-Step Synthesis of Methyl 2-Arylpropanoates from 2-Hydroxypropiophenone Dimethylacetals using Sulfuryl Chloride and an Amide or a Weak Base

Takayoshi Yamauchi* , Kaneaki Hattori, Kenji Nakao, Kentaro Tamaki
  • *Research & Development Laboratory, Sakai Plant, Kyowa Hakko Kogyo Co., Ltd., 1-1-53, Takasu-cho, Sakai-shi, Osaka-fu 590, Japan
Further Information

Publication History

Publication Date:
12 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A facile one-pot method for the preparation of methyl 2-aryl-propanoates 3 from 2-hydroxypropiophenones dimethyl acetals 1 using sulfuryl chloride, pyridine, and dichloromethane is reported. Yields range from 54 to 87% for the aryl groups: phenyl, 4-bromophenyl, 4-methoxyphenyl, 4-isobutylphenyl, and 4-biphenylyl.

      >