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Synthesis 1986; 1986(2): 144-147
DOI: 10.1055/s-1986-31503
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Novel Rigid Calcium-Entry Blockers: Intramolecular Reactions of 1,4-Dihydropyridine Derivatives

David A. Claremon* , Jordan Hirshfield, Patricia K. Lumma, David E. Mcclure, James P. Springer
  • *Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486, U. S. A.
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Publication Date:
20 August 2002 (online)

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The efficient syntheses of rigid molecules related to Ca++ entry antagonists of the 1,4-dihydropyridine type by cyclization of various internal nucleophiles are described.

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