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Synthesis 1986; 1986(1): 69-70
DOI: 10.1055/s-1986-31481
DOI: 10.1055/s-1986-31481
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Eine einfache Synthese von Isoxazol-5-carbonsäure
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Publication Date:
20 August 2002 (online)
A Simple Synthesis of Isoxazole-5-carboxylic Acid Isoxazole-5-carboxylic acid is prepared from trichloroacetyl chloride, ethyl vinyl ether, and hydroxylamine. The intermediates 5-hydroxy-5-trichloromethyl-2-isoxazoline and 5-trichloromethylisoxazole can be isolated. The reaction of 5-trichloromethylisoxazole with trichloroacetic acid leads to isoxazole-5-carboxylic acid chloride and trichloroacetyl chloride.