Download PDF
Open Access
CC BY-NC-ND 4.0 · Asian J Neurosurg
DOI: 10.1055/s-0045-1813648
Research Article

An Observational Study to Identify Various Prognostic Factors in Spinal Metastatic Disease in Northern India

Authors

  • Shubham Gupta 

    1   Department of Neurosurgery, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India

  • Achal Sharma

    1   Department of Neurosurgery, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India

  • Gaurav Jain

    1   Department of Neurosurgery, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India

  • Devendra Kumar Purohit

    1   Department of Neurosurgery, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India
Further Information
Also available at
  Permissions and Reprints

Abstract

Background

Spinal metastatic disease is a common complication in cancer patients, leading to significant morbidity and mortality. These metastases are more frequently found in the bones and may present with symptoms of spinal canal invasion and cord compression. Understanding the prognostic factors influencing outcomes in spinal metastatic disease is crucial for optimizing treatment strategies and improving patient quality of life.

Objective

This study aims to identify and analyze various prognostic factors, including treatment modality (surgical vs. conservative), affecting the clinical outcomes in patients with spinal metastatic disease.

Materials and Methods

A prospective observational study was conducted at a tertiary care center on 50 patients diagnosed with spinal metastatic disease for a year. Data collected included demographic information, primary cancer type, site of primary cancer, neurological status at presentation, treatment modalities employed, and overall survival. Prognostic factors were evaluated using appropriate tests, and data analysis was performed using SPSS software.

Results

The mean age of the patients was 60.7 years, with a male-to-female ratio of 1.4:1. The most common primary cancers were breast (21), lung (17), liver (8), and prostate (4). Key prognostic factors identified included sex (females having a good outcome), number of visceral metastases ≤ 1, hemoglobin, albumin, Karnofsky Performance Status score, pretreatment Klekamp score, and management (surgery).

Conclusion

This study identifies several critical prognostic factors in spinal metastatic disease, including neurological status at presentation, primary tumor type, and treatment modality. These factors should be considered when developing individualized treatment plans for patients with spinal metastatic disease to improve survival and quality of life.

Keywords

histopathology - Klekamp score - prognosis - solid tumor - spinal metastases


Publication History

Article published online:
05 December 2025

© 2025. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India