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DOI: 10.1055/s-0045-1813259
Virtual Reality in Neurosurgery: Advancing Training, Education, and Surgical Planning
Authors
Abstract
Virtual reality (VR) is transforming the vast field of neurosurgery by providing realistic and interactive simulations of intricate brain structures. A literature search of PubMed, Google Scholar, and the Cochrane Library using the keywords “virtual reality,” “VR in neurosurgery,” “skill development,” “neurosurgical education,” “patient outcome,” “3D visualisation,” “evolution in neurosurgery,” and “simulators” was performed. The relevant articles, including RCTs, meta-analyses, and systematic reviews and narrative reviews, were considered from inception up to March 2025. This review of existing literature was conducted to explore the evolution, current applications, and future potential of VR in neurosurgery. Emerging in the early 1990s, it lacked accuracy and precision, but now in the 2020s, it provides exceptional benefits to the field. The findings highlight how VR has enhanced the neurosurgical field through various simulators, optimized strategies and planning and decision making, and improved surgical training. Students of neurosurgery can get trained through various 3D models, providing them with a realistic experience of surgical procedures. Moreover, the integration of artificial intelligence (AI) has further refined surgical decision-making, risk evaluation, and real-time adaptability. However, various challenges exist, making VR accessibility limited. High cost, lack of numerous skilled operators, user discomfort, and no proper ethical protocols are critical hindrances that need to be addressed. VR has evolved into a crucial tool for neurosurgical innovation, although ongoing research needs to refine AI-driven models, expand accessibility, and establish standardized protocols for easy adoption across diverse healthcare settings.
Publication History
Article published online:
03 December 2025
© 2025. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Usachev DY, Konovalov AN, Potapov AA. et al. Modern neurosurgery—the multidisciplinary integration of competences and technologies. Ann Russ Acad Med Sci 2022; 77 (04) 267-275
- 2 Potapov AA, Konovalov AN, Kornienko VN. et al. Current technologies and basic research in neurosurgery. Herald Russ Acad Sci 2015; 85 (02) 112-121
- 3 Weyhe D, Hartmann V, Uslar V, Tabriz N. Augmented and virtual reality in surgery: applications and exploratory studies using VIVATOP as an example. Chirurgie 2025; 96 (01) 31-40
- 4 Alshalchy A, Al-Badri SG, Al-Taie RH, Ismail M. Navigating the complexities of microneurosurgery practice in Iraq. Cureus 2024; 16 (10) e71972
- 5 Spicer MA, van Velsen M, Caffrey JP, Apuzzo ML. Virtual reality neurosurgery: a simulator blueprint. Neurosurgery 2004; 54 (04) 783-797 , discussion 797–798
- 6 Menna G, Riva D, Marino S. et al. Simulation tools in neuro-oncological surgery: a scoping review of perioperative and training applications. J Neurooncol 2025; 173 (01) 21-35
- 7 Kirkman MA, Ahmed M, Albert AF, Wilson MH, Nandi D, Sevdalis N. The use of simulation in neurosurgical education and training. A systematic review. J Neurosurg 2014; 121 (02) 228-246
- 8 Sharma N, Mallela AN, Khan T. et al. Evolution of the meta-neurosurgeon: a systematic review of the current technical capabilities, limitations, and applications of augmented reality in neurosurgery. Surg Neurol Int 2024; 15: 146
- 9 Patel N, Hofmann K, Keating RF. Current applications of VR/AR (virtual reality/augmented reality) in pediatric neurosurgery. In: Advances in Pediatric Neurosurgery. Springer; 2024: 19-34
- 10 Khizar A. Artificial intelligence and neurosurgery: a revolution in the field. Pak J Neurol Sci 2024; 18 (04)
- 11 Kamboh UA, Abid S, Ullah S, Manzoor M, Sultan K, Mehboob M. Virtual reality in neurosurgery—a neurostimulator-based postgraduate residency training: a novel step towards skillful young neurosurgeons. Pak J Neurol Surg. 2022; 26 (03) 536-542
- 12 Fazlollahi AM, Bakhaidar M, Alsayegh A. et al. Effect of artificial intelligence tutoring vs expert instruction on learning simulated surgical skills among medical students: a randomized clinical trial. JAMA Netw Open 2022; 5 (02) e2149008
- 13 Kazemzadeh K, Akhlaghdoust M, Zali A. Advances in artificial intelligence, robotics, augmented and virtual reality in neurosurgery. Front Surg 2023; 10: 1241923
- 14 Alotaibi F, Del Maestro R, AlZhrani G. et al. Utilizing NeuroTouch, a virtual reality simulator, to assess and monitor bimanual performance during brain tumor resection. Can J Neurol Sci 2015; 42 (S1): S20
- 15 Davids J, Manivannan S, Darzi A, Giannarou S, Ashrafian H, Marcus HJ. Simulation for skills training in neurosurgery: a systematic review, meta-analysis, and analysis of progressive scholarly acceptance. Neurosurg Rev 2021; 44 (04) 1853-1867
- 16 Chugh AJ, Pace JR, Singer J. et al. Use of a surgical rehearsal platform and improvement in aneurysm clipping measures: results of a prospective, randomized trial. J Neurosurg 2017; 126 (03) 838-844
- 17 Dodier P, Civilla L, Mallouhi A. et al. An evaluation of physical and augmented patient-specific intracranial aneurysm simulators on microsurgical clipping performance and skills: a randomized controlled study. Neurosurg Focus 2024; 56 (01) E9
- 18 Liu X, Mao J, Sun N. et al. Comparison between the stereoscopic virtual reality display system and conventional computed tomography workstation in the diagnosis and characterization of cerebral arteriovenous malformations. J Digit Imaging 2023; 36 (04) 1910-1918
- 19 Petrone S, Cofano F, Nicolosi F. et al. Virtual-augmented reality and life-like neurosurgical simulator for training: first evaluation of a hands-on experience for residents. Front Surg 2022; 9: 862948
- 20 Ros M, Debien B, Cyteval C, Molinari N, Gatto F, Lonjon N. Applying an immersive tutorial in virtual reality to learning a new technique. Neurochirurgie 2020; 66 (04) 212-218
- 21 Lan L, Mao RQ, Qiu RY, Kay J, de Sa D. Immersive virtual reality for patient-specific preoperative planning: a systematic review. Surg Innov 2023; 30 (01) 109-122
- 22 Wang SS, Zhang SM, Jing JJ. Stereoscopic virtual reality models for planning tumor resection in the sellar region. BMC Neurol 2012; 12 (01) 146
- 23 Mishra R, Narayanan MDK, Umana GE, Montemurro N, Chaurasia B, Deora H. Virtual Reality in Neurosurgery: Beyond Neurosurgical Planning. Int J Environ Res Public Health 2022; 19 (03) 1719
- 24 Anderson RJ, Bauer PR, Arghami A, Haney RM, Reisdorf EM, Baalson K. Virtual reality simulation to improve postoperative cardiothoracic surgical patient outcomes. Am J Crit Care 2025; 34 (02) 111-118
- 25 Greuter L, De Rosa A, Cattin P, Croci DM, Soleman J, Guzman R. Randomized study comparing 3D virtual reality and conventional 2D on-screen teaching of cerebrovascular anatomy. Neurosurg Focus 2021; 51 (02) E18
- 26 Perin A, Galbiati TF, Ayadi R. et al. Informed consent through 3D virtual reality: a randomized clinical trial. Acta Neurochir (Wien) 2021; 163 (02) 301-308
- 27 Stepan K, Zeiger J, Hanchuk S. et al. Immersive virtual reality as a teaching tool for neuroanatomy. Int Forum Allergy Rhinol 2017; 7 (10) 1006-1013
- 28 Dun Z, Zhu S, Jiang H. Benefits of a frame-based stereotactic surgical planning system for the treatment of spontaneous intracerebral haematomas. J Int Med Res 2013; 41 (05) 1550-1559
- 29 Rizzo Jr MG, Costello II JP, Luxenburg D, Cohen JL, Alberti N, Kaplan LD. Augmented reality for perioperative anxiety in patients undergoing surgery: a randomized clinical trial. JAMA Netw Open 2023; 6 (08) e2329310
- 30 Amini A, Allgaier M, Saalfeld S. et al. Virtual reality vs phantom model: benefits and drawbacks of simulation training in neurosurgery. Operative Neurosurgery 2024
- 31 Kockro RA, Amaxopoulou C, Killeen T. et al. Stereoscopic neuroanatomy lectures using a three-dimensional virtual reality environment. Ann Anat 2015; 201: 91-98
- 32 Ekstrand C, Jamal A, Nguyen R, Kudryk A, Mann J, Mendez I. Immersive and interactive virtual reality to improve learning and retention of neuroanatomy in medical students: a randomized controlled study. CMAJ Open 2018; 6 (01) E103-E109
- 33 Shao X, Yuan Q, Qian D. et al. Virtual reality technology for teaching neurosurgery of skull base tumor. BMC Med Educ 2020; 20 (01) 3
- 34 Nicolelis MAL, Alho EJL, Donati ARC. et al. Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study. Sci Rep 2022; 12 (01) 20545
- 35 Bekelis K, Calnan D, Simmons N, MacKenzie TA, Kakoulides G. Effect of an immersive preoperative virtual reality experience on patient reported outcomes: a randomized controlled trial. Ann Surg 2017; 265 (06) 1068-1073
- 36 Tadlock MD, Olson EJ, Gasques D. et al. Mixed reality surgical mentoring of combat casualty care related procedures in a perfused cadaver model: Initial results of a randomized feasibility study. Surgery 2022; 172 (05) 1337-1345
- 37 Dubinski D, Won SY, Hardung C. et al. Enhancing surgical education for medical students through virtual reality: the digital surgical operating theatre tour. World Neurosurg 2025; 194: 123523
- 38 Calabrò RS, Naro A, Russo M. et al. Virtual reality-based rehabilitation in patients with neurological disabilities: a review of the most recent literature. J Neuroeng Rehabil 2023; 20 (01) 15-28
- 39 Patel A, Koshy N, Ortega-Barnett J. et al. Neurosurgical tactile discrimination training with haptic-based virtual reality simulation. Neurol Res 2014; 36 (12) 1035-1039
- 40 Ciechanski P, Cheng A, Lopushinsky S. et al. Effects of transcranial direct-current stimulation on neurosurgical skill acquisition: a randomized controlled trial. World Neurosurg 2017; 108: 876-884.e4
- 41 Lai C, Lui JT, de Lotbiniere-Bassett M. et al. Virtual reality simulation for the middle cranial fossa approach: a validation study. Oper Neurosurg (Hagerstown) 2024; 26 (01) 78-85
- 42 Bolton WS, Sinha R, Cooper S. et al. Recover reality - recover after injury or surgery to the brain and spinal cord with virtual reality: ideal stage 2a clinical feasibility study. J Neuroeng Rehabil 2025; 22 (01) 45
- 43 Westarp E, Saemann A, Zelechovski M. et al. Virtual reality for patient informed consent in skull base tumors and intracranial vascular pathologies: a pilot study. Acta Neurochir (Wien) 2024; 166 (01) 455
- 44 Georgescu RD, Dobrean A, Silaghi CA, Silaghi H. A virtual reality-based intervention for surgical patients: study protocol of a randomized controlled trial. Trials 2021; 22 (01) 289
