PDF herunterladen
Open Access
CC BY 4.0 · Avicenna J Med
DOI: 10.1055/s-0045-1811706
Review Article

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review

Authors

  • Sagad O.O. Mohamed 

    1   Department of pediatrics and child health, University of Khartoum, Khartoum, Sudan

  • Amged Mohammed

    2   Médecins Sans Frontières, Switzerland

  • Fatima S.K. Salih

    1   Department of pediatrics and child health, University of Khartoum, Khartoum, Sudan

  • Hozifa A.M. Elgadal

    3   Department of pediatrics and child health, University of Bahri, Sudan

  • Ayman A.A. Elsamany

    4   Department of Medicine, Ibri Regional Hospital, Oman

  • Mohamed S.K. Salih

    5   Department of Medicine, Harlem Hospital Center, New York, United States

  • Huda M.A. Mustafa

    6   Department of Medicine, Cairo University, Egypt

  • Israa Elawad

    7   Department of pediatrics, Sidra Medicine, Qatar

  • Mona G.A. Ahmedkaroum

    1   Department of pediatrics and child health, University of Khartoum, Khartoum, Sudan

  • Safaa G.A. Saeed

    8   Department of Medicine, University of Medical Sciences and Technology, Sudan

  • Rowa E.A. Ibrahim

    8   Department of Medicine, University of Medical Sciences and Technology, Sudan

  • Esraa A. Mohamedien

    8   Department of Medicine, University of Medical Sciences and Technology, Sudan

  • Aya A.H. Babiker

    8   Department of Medicine, University of Medical Sciences and Technology, Sudan

  • Esraa T. Suliman

    9   Department of Medicine, AL-Neelain University, Sudan

  • Eman O.E. Mohamed

    1   Department of pediatrics and child health, University of Khartoum, Khartoum, Sudan
Weitere Informationen
Auch verfügbar auf
  Lizenzen und Reprints
Preview

Abstract

Sickle cell disease (SCD) is a hereditary hemoglobin disorder characterized by vaso-occlusion and chronic hemolysis, leading to severe complications. Finding cost-effective and reliable biomarkers for predicting disease severity and identifying high-risk patients remains challenging, especially in resource-limited settings. This systematic review evaluates the association between lactate dehydrogenase (LDH) levels measured during clinical steady-state and various complications of SCD to assess its prognostic value. A systematic literature search, adhering to PRISMA guidelines, was conducted across Medline/PubMed, Web of Science, Embase, and ScienceDirect. Eligible studies included all observational studies examining the relationship between LDH levels and subsequent SCD complications. The statistical analyses were performed to calculate the pooled standardized mean difference (SMD) and its 95% confidence interval (CI). A total of 34 studies were included, highlighting significant associations between elevated LDH levels and various SCD-related complications. These included pulmonary arterial hypertension (SMD = 0.454, 95% CI: 0.032–0.875, p = 0.035), stroke risk through transcranial Doppler velocities (SMD = 0.651, 95% CI: 0.459–0.843, p < 0.001), and kidney involvement (SMD = 0.399, 95% CI: 0.014–0.785, p = 0.042). This systematic review reveals a consistent association between elevated steady-state LDH levels and major complications of SCD. The findings suggest a potential role for LDH as a readily available biomarker for SCD severity, underlining its potential for inclusion in clinical assessments of SCD severity, risk stratification, and tailored interventions for high-risk patients.

Keywords

sickle cell disease - complications - lactate dehydrogenase - systematic review


Publikationsverlauf

Artikel online veröffentlicht:
26. September 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India