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CC BY 4.0 · Chinese medicine and natural products 2025; 05(03): e140-e144
DOI: 10.1055/s-0045-1811651
Review Article

Research Progress on the Mechanism of Traditional Chinese Medicine in Treating Chronic Atrophic Gastritis

Authors

  • Jianxin Shen

    1   Department of Traditional Chinese Medicine, People's Hospital of Bayingolin Mongolian Autonomous Prefecture, Korla, Xinjiang, China

  • Ruxia Xue

    2   Department of Traditional Chinese Medicine, Korla Maternal and Child Health and Family Planning Service Center, Korla, Xinjiang, China

  • Dongshan Yin

    1   Department of Traditional Chinese Medicine, People's Hospital of Bayingolin Mongolian Autonomous Prefecture, Korla, Xinjiang, China

  • Xiang Su

    1   Department of Traditional Chinese Medicine, People's Hospital of Bayingolin Mongolian Autonomous Prefecture, Korla, Xinjiang, China

  • Xiaofa Liu

    3   Department of Spleen and Stomach Diseases, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, China

  • Jinfeng Sun

    1   Department of Traditional Chinese Medicine, People's Hospital of Bayingolin Mongolian Autonomous Prefecture, Korla, Xinjiang, China

Funding This study was supported by the Youth Medical Science and Technology Talent Special Research Project of Xinjiang Uygur Autonomous Region Health Commission (WJWY-202440).
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Abstract

Chronic atrophic gastritis (CAG) is a common type of chronic gastric disease characterized by high incidence and a certain tendency toward cancerization. In recent years, with the deepening of related research, it has been found that traditional Chinese medicine (TCM) exerts therapeutic effects on CAG through various signaling pathways. This article systematically reviews and summarizes the literature on TCM treatment of CAG, elaborating on the etiology and pathogenesis of CAG, new ideas from different physicians in treating CAG, and the effects of different TCM monomers and compound prescriptions on signaling pathways such as PI3K-AKT and JAK1/STAT3 to provide a reference for subsequent research on CAG.

Keywords

chronic atrophic gastritis - traditional Chinese medicine - signaling pathways

CRediT Authorship Contribution Statement

Jianxin Shen: Conceptualization, writing original draft, funding acquisition, project administration, and writing-review and editing. Ruxia Xue: Resources, and writing original draft. Dongshan Yin: Conceptualization, investigation, and methodology. Xiang Su: Conceptualization and investigation. Xiaofa Liu: Conceptualization and supervision. Jinfeng Sun: Conceptualization, writing original draft, and writing-review and editing.




Publication History

Received: 21 March 2025

Accepted: 09 July 2025

Article published online:
30 September 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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