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CC BY 4.0 · Avicenna J Med 2025; 15(03): 116-122
DOI: 10.1055/s-0045-1811590
Original Article

Serum Vitamin D Levels in Autoimmune and Non-Autoimmune Hypothyroidism: A Retrospective Study from Jordan

Authors

  • Hadeel Alqurieny

    1   Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan

  • Mohammad Al-Slehat 

    2   Departmant of Internal Medicine, Jordan University Hospital, Amman, Jordan

  • Karam Bdour

    3   Department of Endocrinology, King Hussein Medical Center, Amman, Jordan

  • Roa'a Abedel Razaq Abu Lail

    4   Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan

  • Abdel Qader Abu-Salih

    5   Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

  • Zaid Iyad Mohammad Aldebei

    4   Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan

  • Mohammad Al-Bdour

    5   Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

  • Rula Al Shimi

    5   Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

  • Asmaa Quraan

    1   Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan

  • Abdel Razaq Al Yasin 

    1   Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan

  • Fadi Ayyash

    1   Department of Endocrinology, Queen Rania Al Abdullah Hospital for Children, Royal Jordanian Medical Services, Amman, Jordan
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Abstract

Background

Vitamin D is a steroid hormone primarily produced in the skin. In Jordan, vitamin D deficiency is widespread among the population. This study aims to compare serum vitamin D levels between patients with autoimmune and non-autoimmune hypothyroidism.

Methods

A retrospective observational study was conducted at the Jordanian Royal Medical Services in Jordan from January 2023 to November 2024. Data were gathered from the patient's medical records, including age, gender, vitamin D level, thyroid-stimulating hormone (TSH) value, free thyroxine (FT4) level, anti-thyroid peroxidase, and anti-thyroglobulin levels.

Results

A total of 150 patients were included, aged 5 to 76 years, with a mean age of 39.2 years. The mean vitamin D level was 17.9 ng/mL, indicating widespread deficiency. There was no significant difference in vitamin D levels between patients with autoimmune and non-autoimmune hypothyroidism (p = 0.860), suggesting that vitamin D levels are independent of autoimmune hypothyroidism status. Additionally, there was no significant relationship between vitamin D levels and TSH (ρ = −0.119, p = 0.148) or FT4 (ρ = 0.128, p = 0.123). Age showed a modest negative correlation with TSH levels (ρ = −0.067, p = 0.416) and a positive but nonsignificant correlation with FT4 levels (ρ = 0.024, p = 0.775).

Conclusion

Serum vitamin D levels do not significantly differ between patients with autoimmune and non-autoimmune hypothyroidism, nor do they correlate with TSH levels. Further studies are needed to evaluate vitamin D status in these patient groups.

Keywords

autoimmune hypothyroidism - non-autoimmune hypothyroidism - 25-hydroxyvitaminD - FT4

Authors' Contributions

The authors contributed to the paper as follows: M.A. was responsible for project administration and supervision; H.A., K.B., A.Q., F.A., and A.A. contributed to review and editing; R.A. handled data collection; M.A. contributed to introduction writing; Z.A. conducted statistical analysis, results editing, and writing; R.S. also contributed to methodology writing; and A.A. and L.A. were responsible for discussion writing and editing.




Publikationsverlauf

Artikel online veröffentlicht:
14. Oktober 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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