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CC BY 4.0 · Journal of Coloproctology 2025; 45(03): s00451811263
DOI: 10.1055/s-0045-1811263
Case Report

Enhancing Proctological Outcomes: The Role of Hyaluronic Acid in Hemorrhoid Care – An Innovative Adjunct to Surgery

Autoren

  • Riddhi Upadhyay 

    1   Department of General Surgery, Shree Krishna Hospital, Pramukh Swami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India

  • Akshat Vadaliya 

    1   Department of General Surgery, Shree Krishna Hospital, Pramukh Swami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India

  • Haryax V. Pathak 

    1   Department of General Surgery, Shree Krishna Hospital, Pramukh Swami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India

  • Soham Upadhyay 

    2   Department of General Surgery, Narendra, Narendra Modi Medical College, Gujarat Univeristy, Ahmedabad, Gujarat, India

Funding The author(s) received no financial support for the research.
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Abstract

Introduction

Hemorrhoids are common anorectal conditions characterized by swollen and inflamed veins in the rectal and anal regions. They are classified as internal, external, or mixed, and may present with rectal bleeding, pain, itching, and prolapse. Chronic constipation, prolonged straining, and increased intra-abdominal pressure are frequent etiological factors. Management strategies range from conservative measures, such as dietary modifications and topical agents, to surgical procedures including hemorrhoidectomy and stapled hemorrhoidopexy.

Objective

To describe the therapeutic potential of hyaluronic acid (HA) in the management of hemorrhoids and to report clinical outcomes in patients treated with HA infiltration.

Results

Five patients with hemorrhoids underwent HA infiltration. Treatment was associated with significant symptom relief, reduced edema, and improved post-surgical recovery. The mechanism of action involved enhanced fibroblast activity, decreased inflammatory cytokines, and improved mucosal hydration.

Conclusion

Hyaluronic acid demonstrates promising results as a safe and effective option for hemorrhoid management. Its hydrating, anti-inflammatory, and wound-healing properties support its role as a versatile therapeutic agent in both conservative and surgical settings, contributing to improved patient outcomes.

Keywords

hemorrhoids - hemorrhoidectomy - hyaluronic acid - proctology

Authors' Contributions

RU: conceptualization, methodology, investigation, writing – original draft; AV: data curation, formal analysis, writing – review & editing; HVP: resources, validation, writing – review & editing; SU: supervision, project administration, writing – review & editing.


Data Availability Statement

The data that support the findings of this study are available from the authors upon reasonable request.


ORCID IDs

Riddhi Upadhyay – https://orcid.org/0009-0008-4837-9255

Akshat Vadaliya – https://orcid.org/0009-0004-9490-4656

Haryax V. Pathak – https://orcid.org/0000-0003-3683-3672

Soham Upadhyay – https://orcid.org/0009-0008-4218-3390




Publikationsverlauf

Eingereicht: 09. April 2025

Angenommen: 21. Juli 2025

Artikel online veröffentlicht:
16. Oktober 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Riddhi Upadhyay, Akshat Vadaliya, Haryax V. Pathak, Soham Upadhyay. Enhancing Proctological Outcomes: The Role of Hyaluronic Acid in Hemorrhoid Care – An Innovative Adjunct to Surgery. Journal of Coloproctology 2025; 45: s00451811263.
DOI: 10.1055/s-0045-1811263