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CC BY 4.0 · Journal of Coloproctology 2025; 45(03): s00451811259
DOI: 10.1055/s-0045-1811259
Original Article

Evaluation of the Prognostic Utility of the Postoperative Inflammatory Burden Index in Colorectal Cancer

Shunsuke Furukawa 
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Masatsugu Hiraki
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Naoya Kimura
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Naohiko Kohya
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Masashi Sakai
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Akashi Ikubo
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
,
Ryuichiro Samejima
1   Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga, Japan
› Institutsangaben
Funding The author(s) received no financial support for the research.
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Abstract

Introduction

This study aimed to evaluate the significance of the postoperative inflammatory burden index (IBI) as a prognostic marker and to investigate the clinical outcomes of patients with stage II and III colorectal cancer who underwent colorectal surgery.

Methods

This retrospective study included 223 patients who underwent colorectal surgery for stage II and III colorectal cancers. The patients were divided into four groups based on postoperative IBI on days 1 and 7 (high or low): Group 1 (low & low, n = 118), Group 2 (high & low, n = 18), Group 3 (low & high, n = 56), and Group 4 (high & high, n = 31). The clinical impact of the postoperative IBI on recurrence-free survival (RFS) and overall survival (OS) was also evaluated.

Results

High postoperative IBI was significantly associated with decreased RFS and OS. The Kaplan-Meier survival curves for RFS and OS in stage II and III colorectal cancer showed a decline in Groups 2, 3, and 4, with a more pronounced decline observed in Group 4 (p = 0.001 and p = 0.007, respectively).

Conclusions

This study suggests that the postoperative IBI may be a prognostic marker for RFS and OS in patients with stage II and III colorectal cancer. When postoperative IBI on days 1 and 7 is high, these findings may indicate a high-risk factor for the recurrence of colorectal cancer. Postoperative IBI is useful in establishing postoperative oncological surveillance and adjuvant chemotherapy strategies.

Keywords

Inflammatory burden index - colorectal cancer - stage II and III - postoperative

Availability of Data and Materials

The data generated in the present study may be requested from the corresponding author.


Authors' Contribution

SF: study design, data collection, interpretation of results, manuscript writing, manuscript editing; MH: study design, data collection, data analysis, interpretation of results, manuscript writing, manuscript editing; NK: data collection, manuscript editing; NKo: data collection, manuscript editing; MS: data collection, manuscript editing; AI: data collection, manuscript editing; RS: data collection, manuscript editing, study supervision, final manuscript approval. All authors read and approved the final manuscript.


Ethics Approval and Consent to Participate

The Medical Ethics Committee of the Japanese Red Cross Society Karatsu Red Cross Hospital reviewed and approved the study design (permission number: 23-I-17–01). All the patients and their families were informed of the surgical procedure and provided written informed consent.


Consent for Publication

Informed broad consent for this study was obtained.




Publikationsverlauf

Eingereicht: 09. März 2025

Angenommen: 22. Mai 2025

Artikel online veröffentlicht:
10. September 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Shunsuke Furukawa, Masatsugu Hiraki, Naoya Kimura, Naohiko Kohya, Masashi Sakai, Akashi Ikubo, Ryuichiro Samejima. Evaluation of the Prognostic Utility of the Postoperative Inflammatory Burden Index in Colorectal Cancer. Journal of Coloproctology 2025; 45: s00451811259.
DOI: 10.1055/s-0045-1811259