PDF icon PDF herunterladen
Open Access
CC BY 4.0 · Journal of Digestive Endoscopy 2025; 16(03): 172-173
DOI: 10.1055/s-0045-1810416
Learning Images

Rectal Melanoma with Solitary Pancreatic Metastasis

Abhishek Yadav 
1   Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Sanish Ancil
1   Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Radhika Srinivasan
2   Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Rajesh Gupta
3   Department of Gastrointestinal Surgery, Hepato-Pancreatic-Biliary and Liver Transplantation, Postgraduate Institute of Medical Education and Research, Chandigarh, India
› Institutsangaben
Funding None.
› Weitere Informationen
Auch verfügbar aufeRef
  Lizenzen und Reprints
Preview

A 45-year-old asymptomatic female diagnosed with rectal melanoma 1 year back, on immunotherapy, was referred for evaluation of a pancreatic head lesion of size 3.18 × 3.25 cm, detected on routine follow-up 18F-fluorodeoxyglucose positron emission tomography with maximum standardized uptake value 15.63 ([Fig. 1]). Endoscopic ultrasound (EUS) assessment revealed a well-defined hypoechoic mass lesion in the head of the pancreas, closely abutting the main portal vein ([Fig. 2]). The lesion was stiff on EUS elastography and showed hyperenhancement with rapid washout on intravenous contrast ([Fig. 3]). Histopathology of tissue specimen acquired under EUS guidance revealed many singly scattered tumor cells with round to oval nuclei with opened up chromatin admixed with pancreatic acinar cells, consistent with the diagnosis of metastatic melanoma ([Fig. 4]).

Zoom
Fig. 1 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): FDG-avid lesion in the head of the pancreas.
Zoom
Fig. 2 Endoscopic ultrasound (EUS): Well-defined hypoechoic lesion in the head of the pancreas.
Zoom
Fig. 3 Contrast-enhanced endoscopic ultrasound (EUS): The pancreatic lesion is hyperenhancing.
Zoom
Fig. 4 Microphotograph showing large atypical cells with opened up chromatin and prominent nucleoli admixed with pancreatic acinar cells (May–Grunwald Giemsa stain ×400).


Publikationsverlauf

Artikel online veröffentlicht:
28. Juli 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Zerbi A, Pecorelli N. Pancreatic metastases: an increasing clinical entity. World J Gastrointest Surg 2010; 2 (08) 255-259
    Suche in Google Scholar
  • 2 Konstantinidis IT, Dursun A, Zheng H. et al. Metastatic tumors in the pancreas in the modern era. J Am Coll Surg 2010; 211 (06) 749-753
    Suche in Google Scholar
  • 3 Balch CM, Gershenwald JE, Soong SJ. et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27 (36) 6199-6206
    Suche in Google Scholar