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DOI: 10.1055/s-0045-1810100
Advanced T-cell Lymphoma with Penile Involvement Revealed by 18F-FDG PET/CT: A Rare Presentation
Abstract
T-cell lymphomas are rare malignancies that frequently involve extranodal sites, but penile localization remains exceedingly uncommon. We report the case of a 21-year-old man diagnosed with cutaneous T-cell lymphoma who underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for initial staging. The scan revealed widespread nodal and extranodal disease, including unexpected intense fluorodeoxyglucose uptake in the corpora cavernosa, in the absence of penile symptoms. Penile involvement in lymphoma, whether primary or secondary, Hodgkin or non-Hodgkin, is exceptionally rare, with very few cases reported—most involving B cell histologies. This finding underscores the utility of PET/CT in identifying clinically silent and atypical disease sites in aggressive lymphomas such as peripheral T-cell lymphoma. The extent of dissemination, including renal, adrenal, bone marrow, and penile involvement, reflects a high tumor burden and portends a poor prognosis. Early recognition of such patterns through PET/CT is essential for appropriate therapeutic planning and may impact patient outcomes.
Publication History
Article published online:
18 July 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Vose JM. Peripheral T-cell non-Hodgkin's lymphoma. Hematol Oncol Clin North Am 2008; 22 (05) 997-1005 , x
- 2 Vose J, Armitage J, Weisenburger D. International T-Cell Lymphoma Project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008; 26 (25) 4124-4130
- 3 Willemze R, Jaffe ES, Burg G. et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105 (10) 3768-3785
- 4 Arambulo S, Calle A, Vela JM, Sotelo MJ. Advanced penile lymphoma: case report and review of the literature. J Cancer Res Ther 2023; 19 (03) 823-825
- 5 Diao L, Yang S, Shang P, Hou Z. Report of penis lymphoma and review of the literature. Asian J Surg 2022; 45 (11) 2528-2529
- 6 Schniederjan SD, Osunkoya AO. Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases. Mod Pathol 2009; 22 (08) 1057-1065
- 7 Nakayama F, Sheth S, Caskey CI, Hamper UM. Penile metastasis from prostate cancer: diagnosis with sonography. J Ultrasound Med 1997; 16 (11) 751-753
- 8 Naik N, Lin M, Lin P. Genitourinary involvement of lymphomas on FDG-PET. Br J Radiol 2018; 91 (1086): 20170273
- 9 Feeney J, Horwitz S, Gönen M, Schöder H. Characterization of T-cell lymphomas by FDG PET/CT. AJR Am J Roentgenol 2010; 195 (02) 333-340
- 10 El-Galaly TC, Villa D, Gormsen LC, Baech J, Lo A, Cheah CY. FDG-PET/CT in the management of lymphomas: current status and future directions. J Intern Med 2018; 284 (04) 358-376
- 11 Savage KJ. Peripheral T-cell lymphomas. Blood Rev 2007; 21 (04) 201-216
- 12 Luan Y, Li X, Luan Y. et al. Therapeutic challenges in peripheral T-cell lymphoma. Mol Cancer 2024; 23 (01) 2