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DOI: 10.1055/s-0045-1809908
Percutaneous Image-Guided Cryoablation of Recurrent Myxofibrosarcoma in the Forearm: A Case Report and Review of Literature
Funding None.
Abstract
Myxofibrosarcoma (MFS) is a rare, aggressive soft tissue sarcoma with high recurrence rates. Conventional treatment involves wide surgical resection and radiotherapy, but the infiltrative nature of MFS often complicates complete resection. This case highlights an 81-year-old patient with recurrent MFS in the left forearm, initially treated with surgery and radiation therapy. Due to surgical limitations and desire for a minimally invasive approach after recurrence, cryoablation was performed. The patient underwent the procedure successfully, and postoperative imaging indicated effective ablation. This case demonstrates cryoablation as a feasible, minimally invasive alternative for managing recurrent MFS, particularly in anatomically challenging cases.
Ethical Approval
Research Ethics Board approval was waived per standard policy for case reports and/or series.
Publication History
Article published online:
03 July 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Willems SM, Debiec-Rychter M, Szuhai K, Hogendoorn PCW, Sciot R. Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol 2006; 19 (03) 407-416
- 2 Kang S, Kim HS, Kim W, Kim JH, Kang SH, Han I. Comorbidity is independently associated with poor outcome in extremity soft tissue sarcoma. Clin Orthop Surg 2015; 7 (01) 120-130
- 3 van Herk-Sukel MPP, Shantakumar S, Overbeek LIH, van Boven H, Penning-van Beest FJA, Herings RMC. Occurrence of comorbidities before and after soft tissue sarcoma diagnosis. Sarcoma 2012; 2012: 402109
- 4 Manoso MW, Pratt J, Healey JH, Boland PJ, Athanasian EA. Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res 2006; 450 (450) 89-94
- 5 Erinjeri JP, Clark TWI. Cryoablation: mechanism of action and devices. J Vasc Interv Radiol 2010; 21 (8, Suppl): S187-S191
- 6 Pal K, Awad A, Yevich S. et al. Safety and efficacy of percutaneous cryoablation for recurrent or metastatic soft-tissue sarcoma in adult patients. AJR Am J Roentgenol 2024; 223 (04) e2431490
- 7 Bodard S, Geevarghese R, Razakamanantsoa L. et al. Percutaneous cryoablation in soft tissue tumor management: an educational review. Insights Imaging 2024; 15 (01) 278
- 8 Auloge P, Cazzato RL, Rousseau C. et al. Complications of percutaneous bone tumor cryoablation: a 10-year experience. Radiology 2019; 291 (02) 521-528
- 9 Chen C, Garlich J, Vincent K, Brien E. Postoperative complications with cryotherapy in bone tumors. J Bone Oncol 2017; 7: 13-17
- 10 Papalexis N, Savarese LG, Peta G. et al. The new ice age of musculoskeletal intervention: role of percutaneous cryoablation in bone and soft tissue tumors. Curr Oncol 2023; 30 (07) 6744-6770
- 11 Lippa N, Sargos P, Italiano A. et al. Standardization of selection criteria for percutaneous image-guided cryoablation of recurrent soft-tissue sarcomas. Diagn Interv Imaging 2014; 95 (11) 1071-1077
- 12 Maybody M, Tang PQ, Moskowitz CS, Hsu M, Yarmohammadi H, Boas FE. Pneumodissection for skin protection in image-guided cryoablation of superficial musculoskeletal tumours. Eur Radiol 2017; 27 (03) 1202-1210
- 13 Sag AA, Riedel RF, Eward WC, Visgauss JD, Brigman BE. Hydropneumodissection-assisted cryoablation of recurrent sarcoma adjacent to the sciatic nerve as a limb-sparing alternative to hindquarter amputation. J Vasc Interv Radiol 2023; 34 (05) 923-926.e1
- 14 Cazzato RL, Gantzer J, de Marini P. et al. Sporadic desmoid tumours: systematic review with reflection on the role of cryoablation. Cardiovasc Intervent Radiol 2022; 45 (05) 613-621
- 15 Kwak K, Yu B, Lewandowski RJ, Kim DH. Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation. Theranostics 2022; 12 (05) 2175-2204
- 16 Kim DK, Won JY, Park SY. Percutaneous cryoablation for renal cell carcinoma using ultrasound-guided targeting and computed tomography-guided ice-ball monitoring: radiation dose and short-term outcomes. Acta Radiol 2019; 60 (06) 798-804
- 17 Won JY, Kim DK, Park SY. Renal mass cryoablation: melting time analysis of radiographic ice-ball after 5-minute active thawing by using serial ultrasound. Eur J Radiol 2021; 134: 109409
- 18 Al-Assam H, Botchu R, Azzopardi C, Stevenson JD, James SL, Patel A. Measurement analysis of ice ball size during CT-guided cryoablation procedures for better prediction of final ice ball size and avoidance of complications. Indian J Radiol Imaging 2023; 33 (03) 321-326
- 19 Havez M, Lippa N, Al-Ammari S. et al. Percutaneous image-guided cryoablation in inoperable extra-abdominal desmoid tumors: a study of tolerability and efficacy. Cardiovasc Intervent Radiol 2014; 37 (06) 1500-1506
- 20 Mandel JE, Kim D, Yarmohammadi H. et al. Percutaneous cryoablation provides disease control for extra-abdominal desmoid-type fibromatosis comparable with surgical resection. Ann Surg Oncol 2022; 29 (01) 640-648