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DOI: 10.1055/s-0045-1809653
Imaging Approach to Infertility
Funding This research did not receive any financial grant from funding agencies in the public or commercial sectors.

Abstract
This review highlights the role of imaging in the evaluation of female infertility. The multifactorial origin, role of different imaging modalities, and key imaging findings are emphasized. It features all the tubal, uterine, cervical, vaginal, and ovarian pathologies accounting for female infertility and detected by imaging. The role of hysterosalpingography (HSG), pelvic ultrasound (USG), sono-HSG, and magnetic resonance imaging (MRI) of the female reproductive tract is discussed. In addition, the advances in imaging, including contrast-enhanced sono-HSG, sonoelastography, and MR HSG are reviewed. Though hysterolaparoscopy is the gold standard, USG is usually the first-line investigation, and MRI expands the frontiers of knowledge due to its enhanced soft-tissue resolution and multiplanar imaging capabilities. Though the initial clinical evaluation of infertility lays stress on serum hormonal evaluation and detecting ovulation, imaging plays a pivotal role in evaluating certain causes confined to the uterus or ovaries. The need of the hour is to develop an all-inclusive, integrated imaging strategy for the evaluation of female infertility. The current proposal is to combine Fertiliscan, a combination of high-quality 3D USG and assessment of tubal patency by sono-HSG and MR HSG, to look for detailed anatomy in one go. Nevertheless, exhaustive research is needed to establish their reliability, safety, and cost-effectiveness, especially in the resource-limited settings of Southeast Asia.
Ethics Approval and Consent to Participate
A written approval was obtained from the participant.
Consent for Publication
The authors consented to the submission of the manuscript and publication. The authors disclosed no competing interests and no relevant relationships.
Availability of Data and Materials
The cases and the images are available from the Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Authors' Contributions
N.B. is the corresponding author and designed and revised the work, interpreted the data, and submitted the case. N.B. has approved the submitted version for publication. A.A.J. and N.B. drafted the work and approved the submitted version for publication. R.M. has revised the manuscript and approved the submitted version for publication. R.M. and A.B. have revised the work. No disclosure. All authors read and approved the final manuscript.
Publication History
Article published online:
12 June 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Katole A, Saoji AV. Prevalence of primary infertility and its associated risk factors in urban population of central India: a community-based cross-sectional study. Indian J Community Med 2019; 44 (04) 337-341
- 2 Agiwal V, Madhuri RS, Chaudhuri S. Infertility burden across Indian states: insights from a nationally representative survey conducted during 2019-21. J Reprod Infertil 2023; 24 (04) 287-292
- 3 Imaoka I, Wada A, Matsuo M, Yoshida M, Kitagaki H, Sugimura K. MR imaging of disorders associated with female infertility: use in diagnosis, treatment, and management. Radiographics 2003; 23 (06) 1401-1421
- 4 Cue L, Mayer C, Martingano DJ. Hysterosalpingogram. [Updated 2024 May 6]. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2025
- 5 Chalazonitis A, Tzovara I, Laspas F, Porfyridis P, Ptohis N, Tsimitselis G. Hysterosalpingography: technique and applications. Curr Probl Diagn Radiol 2009; 38 (05) 199-205
- 6 Wu V, Mar W, Milad MP, Horowitz JM. Magnetic resonance imaging in the evaluation of female infertility. Curr Probl Diagn Radiol 2022; 51 (02) 181-188
- 7 Wang XL, Lin S, Lyu GR. Advances in the clinical application of ultrasound elastography in uterine imaging. Insights Imaging 2022; 13 (01) 141
- 8 Dishuck CF, Perchik JD, Porter KK, Gunn DD. Advanced imaging in female infertility. Curr Urol Rep 2019; 20 (11) 77
- 9 Sadow CA, Sahni VA. Imaging female infertility. Abdom Imaging 2014; 39 (01) 92-107
- 10 Woodward PJ, Wagner BJ, Farley TE. MR imaging in the evaluation of female infertility. Radiographics 1993; 13 (02) 293-310
- 11 Pfeifer SM, Attaran M, Goldstein J. et al. ASRM Müllerian anomalies classification 2021. Fertil Steril 2021; 116 (05) 1238-1252
- 12 Grimbizis GF, Gordts S, Di Spiezio Sardo A. et al. The ESHRE/ESGE consensus on the classification of female genital tract congenital anomalies. Hum Reprod 2013; 28 (08) 2032-2044
- 13 Van den Bosch T, Dueholm M, Leone FP. et al. Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group. Ultrasound Obstet Gynecol 2015; 46 (03) 284-298
- 14 Gomez E, Nguyen MT, Fursevich D, Macura K, Gupta A. MRI-based pictorial review of the FIGO classification system for uterine fibroids. Abdom Radiol (NY) 2021; 46 (05) 2146-2155
- 15 Legendre G, Catala L, Morinière C. et al. Relationship between ovarian cysts and infertility: what surgery and when?. Fertil Steril 2014; 101 (03) 608-614
- 16 Hoeger KM, Dokras A, Piltonen T. Update on PCOS: consequences, challenges, and guiding treatment. J Clin Endocrinol Metab 2021; 106 (03) e1071-e1083
- 17 Coutinho Jr A, Bittencourt LK, Pires CE. et al. MR imaging in deep pelvic endometriosis: a pictorial essay. Radiographics 2011; 31 (02) 549-567
- 18 Rousset P, Florin M, Bharwani N. et al; ENDOVALIRM Group. Deep pelvic infiltrating endometriosis: MRI consensus lexicon and compartment-based approach from the ENDOVALIRM group. Diagn Interv Imaging 2023; 104 (03) 95-112
- 19 Lorusso F, Scioscia M, Rubini D. et al. Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings. Insights Imaging 2021; 12 (01) 105
- 20 Garry R. Is insulin resistance an essential component of PCOS? The endometriosis syndromes: a clinical classification in the presence of aetiological confusion and therapeutic anarchy. Hum Reprod 2004; 19 (04) 760-768