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DOI: 10.1055/s-0045-1809644
The Effect of Oleuropein on the Treatment of Allergic Rhinitis
Funding The authors declare that the present study was conducted with the support of Türkiye Bilim Teknik ve Araştırma Kurumu (TÜBĪTAK) 3001 project (no: 317S048).
Abstract
Introduction
Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature.
Objective
To investigate the effects of general and topical oleuropein during the allergic rhinitis period and the histopathological changes in the nasal mucosa compared with steroid nasal sprays and control group in rats.
Methods
We developed an experimental animal model with 44 rats divided into 6 groups. Except for the control group, the allergic rhinitis in the other five groups was created with ovalbumin. As treatment, saline was administered to group 3, steroids, to group 4, oleuropein, to group 5, and steroids and oleuropein were administered to group 6. The effects of the drugs were examined histopathologically and the levels of immunoglobulin E (IgE) in the blood were compared.
Results
Considering the symptomatic findings in rats, we could observe that allergic rhinitis occurred. Based on the IgE levels and histopathological findings, we have statistically shown that oleuropein may be effective in treatment of allergy rhinitis.
Conclusion
Oleuropein has been shown to be useful in the treatment of allergic rhinitis in an animal model, but further studies are needed before it is introduced into the medical practice.
Ethical Consideration
The institutional Animal Ethics Committee approved the present study (2017/08-11; date: August 25, 2017).
Publication History
Received: 22 May 2024
Accepted: 24 March 2025
Article published online:
20 August 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Özge Çaglar Cil, Basak Büyük, Hüseyin Avni Eroglu, Hilal Sehitoglu. The Effect of Oleuropein on the Treatment of Allergic Rhinitis. Int Arch Otorhinolaryngol 2025; 29: s00451809644.
DOI: 10.1055/s-0045-1809644
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References
- 1 De S, Fenton JE, Jones AS. Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease. J Laryngol Otol 2005; 119 (06) 436-442
- 2 Nagai H, Teramachi H, Tuchiya T. Recent advances in the development of anti-allergic drugs. Allergol Int 2006; 55 (01) 35-42
- 3 Greiner AN, Meltzer EO. Overview of the treatment of allergic rhinitis and nonallergic rhinopathy. Proc Am Thorac Soc 2011; 8 (01) 121-131
- 4 Kayasuga R, Iba Y, Hossen MA, Watanabe T, Kamei C. The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice. Int Immunopharmacol 2003; 3 (04) 469-473
- 5 Soler-Rivas C, Espin JC, Wichers HJ. Oleuropein and related compounds. J Sci Food Agric 2000; 80 (07) 1013-1023 10.1002/(SICI)1097-0010(20000515)80:7<1013::AID-JSFA571>3.0.CO;2-C
- 6 Sagit M, Polat H, Gurgen SG, Berk E, Guler S, Yasar M. Effectiveness of quercetin in an experimental rat model of allergic rhinitis. Eur Arch Otorhinolaryngol 2017; 274 (08) 3087-3095
- 7 Avincsal MO, Ozbal S, Ikiz AO, Pekcetin C, Güneri EA. Effects of topical intranasal doxycycline treatment in the rat allergic rhinitis model. Clin Exp Otorhinolaryngol 2014; 7 (02) 106-111
- 8 Wang J, Guo Z, Zhang R, Han Z, Huang Y, Deng C. et al. Effects of N-acetylcysteine on oxidative stress and inflammation reactions in a rat model of allergic rhinitis after PM2.5 exposure. Biochem Biophys Res Commun 2020; 533 (03) 275-281
- 9 Guibas GV, Spandou E, Meditskou S, Vyzantiadis TA, Priftis KN, Anogianakis G. N-acetylcysteine exerts therapeutic action in a rat model of allergic rhinitis. Int Forum Allergy Rhinol 2013; 3 (07) 543-549
- 10 Sakat MS, Kilic K, Kandemir FM, Yildirim S, Sahin A, Kucukler S, Saglam YS. The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. Eur Arch Otorhinolaryngol 2018; 275 (10) 2495-2505
- 11 Jiang JF, Deng Y, Xue W, Zheng TP, Sun AJ. Increased expression of interleukin 37 in the eutopic and ectopic endometrium of patients with ovarian endometriosis. Reprod Sci 2016; 23 (02) 244-248
- 12 Akşit E, Büyük B, Oğuz S. Histopathological changes in myocardial tissue due to coronary venous hypertension. Arch Med Sci 2020; 19 (06) 1714-1720
- 13 Beyazit F, Büyük B, Turkon H, Elmas S, Uzun M. Adalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation. J Obstet Gynaecol Res 2019; 45 (02) 358-367
- 14 Assanasen P, Baroody FM, Rouadi P, Naureckas E, Solway J, Naclerio RM. Ipratropium bromide increases the ability of the nose to warm and humidify air. Am J Respir Crit Care Med 2000; 162 (3 Pt 1): 1031-1037
- 15 Petroni A, Blasevich M, Salami M, Papini N, Montedoro GF, Galli C. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb Res 1995; 78 (02) 151-160
- 16 Ribeiro RdA, Melo MMFd, Barros FD, Gomes C, Trolin G. Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of São Paulo. J Ethnopharmacol 1986; 15 (03) 261-269
- 17 Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter M-H. Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung 2002; 52 (11) 797-802
- 18 Visioli F, Bellomo G, Montedoro G, Galli C. Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents. Atherosclerosis 1995; 117 (01) 25-32
- 19 Şimsek T, Erbas M, Buyuk B, Pala C, Şahin H, Altinisik B. Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits1. Acta Cir Bras 2018; 33 (11) 954-963
- 20 Wen WD, Yuan F, Wang JL, Hou YP. Botulinum toxin therapy in the ovalbumin-sensitized rat. Neuroimmunomodulation 2007; 14 (02) 78-83
- 21 Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK. et al. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol 2008; 121 (05) 1225-1231
- 22 Kim Y-H, Choi Y-J, Kang M-K, Lee E-J, Kim DY, Oh H, Kang Y-H. Oleuropein Curtails Pulmonary Inflammation and Tissue Destruction in Models of Experimental Asthma and Emphysema. J Agric Food Chem 2018; 66 (29) 7643-7654
- 23 Persia FA, Mariani ML, Fogal TH, Penissi AB. Hydroxytyrosol and oleuropein of olive oil inhibit mast cell degranulation induced by immune and non-immune pathways. Phytomedicine 2014; 21 (11) 1400-1405
- 24 Gambino CM, Accardi G, Aiello A, Candore G, Dara-Guccione G, Mirisola M. et al. Effect of extra virgin olive oil and table olives on the immuneinflammatory responses: potential clinical applications. Endocr Metab Immune Disord Drug Targets 2018; 18 (01) 14-22