General Overview of Intracranial Meningiomas: 11 Years of Experience in an Oncological Reference Center

Abstract

Objective

To perform the clinical and therapeutic follow-up of patients with meningioma and to evaluate the risk and protective factors for the outcomes obtained during the treatment.

Materials and Methods

We conducted a retrospective cohort study using clinical, radiological, and histopathological data contained in the records of patients with meningiomas; we also performed retrospective monitoring for 5 years, evaluating the initial symptoms and clinical evolution, demographic data, risk factors, location, laterality and dimensions, treatment, complete radiological resection, death, additional deficits, and changes in the performance score.

Results

We followed up a sample of 86 patients with a mean age of 47 years and a predominance of female subjects. The most frequent histological types were the meningothelial, followed by the fibrous, the transitional subtype, and the mixed and psamomatous subtypes. Grade-II and -III injuries represented 8.13% and 3.12% of the total respectively. The initial clinical conditions presented nonspecific signs in 79% of the individuals and focal neurological signs in 12%, the most common being appendicular deficit, unilateral amaurosis, and cranial nerve syndrome. Regarding treatment distribution, all patients studied underwent surgical resection (Simpson 1: 15%; Simpson 2: 12%; Simpson 3: 35%; and Simpson 4: 36%), with a good correlation of the total radiological resection for the first 3 degrees.

Conclusion

Thus, the need for early diagnosis and therapy is emphasized to achieve a better outcome, and we recommend the performance of prospective studies that evaluate other variables to clarify the risk factors for mortality and recurrence.

Resumo

Objetivo

Realizar o acompanhamento clínico e terapêutico de pacientes com meningioma e avaliar os fatores de risco e protetores para os desfechos obtidos durante o tratamento.

Materiais e Métodos

Conduziu-se um estudo de coorte retrospectivo em que foram utilizados os dados clínicos, radiológicos e histopatológicos dos registros de pacientes com meningiomas, e foi realizado um acompanhamento retrospectivo de 5 anos, com avaliação dos sintomas iniciais e da evolução clínica, dados demográficos, fatores de risco, localização, lateralidade e dimensões, tratamento, ressecção radiológica completa, óbito, déficits adicionais e alterações na pontuação de desempenho.

Resultados

Foi acompanhada uma amostra de 86 pacientes com idade média de 47 anos e predominância do sexo feminino. Os tipos histológicos mais frequentes foram o meningotelial, seguido pelo fibroso, o subtipo de transição e os subtipos misto e psamomatoso. As lesões de graus II e III representaram 8,13% e 3,12% do total, respectivamente. As condições clínicas iniciais apresentaram sinais inespecíficos em 79% dos indivíduos e sinais neurológicos focais em 12%, sendo os mais comuns o déficit apendicular, amaurose unilateral e síndrome do nervo craniano. Na distribuição do tratamento, todos os pacientes estudados foram submetidos à ressecção cirúrgica (Simpson 1: 15%; Simpson 2: 12%; Simpson 3: 35%; e Simpson 4: 36%), com boa correlação da ressecção radiológica total para os primeiros 3 graus.

Conclusão

Assim, enfatiza-se a necessidade de diagnóstico e terapia precoces para se alcançar um melhor resultado, e recomenda-se a realização de estudos prospectivos que avaliem outras variáveis para esclarecer os fatores de risco para mortalidade e recorrência.

Keywords

meningioma - follow-up - survival analysis - neurosurgery

Palavras-chave

meningioma - seguimento - análise de sobrevida - neurocirurgia

Publikationsverlauf

Eingereicht: 02. November 2024

Angenommen: 28. März 2025

Artikel online veröffentlicht:
01. Juli 2025

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