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DOI: 10.1055/s-0045-1809512
Efeitos da infiltração intra-articular de aspirado de medula óssea no tratamento da osteoartrite de joelho: Estudo clínico comparando BMA versus corticosteroide e bloqueio genicular
Effects of Intra-articular Bone Marrow Aspirate Infiltration in the Treatment of Knee Osteoarthritis: A Clinical Study Comparing BMA versus Corticosteroid and Genicular Block
Resumo
Objetivo Avaliar a eficácia do aspirado de medula óssea autólogo (BMA) na redução da dor e melhora da funcionalidade em pacientes com osteoartrite (OA) de joelho, comparando com a infiltração intra-articular com corticoide e bloqueio genicular.
Métodos Um estudo clínico prospectivo, randomizado, controlado, simples-cego, comparativo e analítico foi realizado. Foram 50 pacientes com OS de joelho, divididos em dois grupos: um grupo de intervenção submetido ao tratamento com BMA e um grupo controle submetido à infiltração articular padrão com corticoide e bloqueio genicular. Os resultados foram avaliados usando o Índice de Osteoartrite das Universidades de Western Ontario e McMaster (WOMAC).
Resultados Após 6 meses, uma redução significativa da dor foi observada no grupo BMA em comparação ao grupo controle (p = 0.030). Não foram encontradas diferenças significativas nos escores de rigidez e atividade física entre os grupos. O grupo de intervenção demonstrou melhorias significativas em todas as subcategorias do WOMAC avaliadas antes e após o tratamento.
Conclusão O tratamento com BMA pode reduzir significativamente a dor, possibilitando uma melhora funcional, sugerindo seu potencial como opção terapêutica viável no manejo da OA de joelho.
Abstract
Objective To assess the efficacy of autologous bone marrow aspirate (BMA) in reducing pain and improving functionality in patients with knee osteoarthritis (OA), in comparison with intraarticular corticosteroid injection and genicular nerve block.
Methods A prospective, randomized, controlled, single-blinded, comparative, and analytical clinical study was conducted. There were 50 patients with knee OA divided into two groups: an intervention group receiving BMA treatment and a control group undergoing standard corticosteroid articular infiltration and genicular block. Outcome measures were evaluated using the Western Ontario and McMaster universities osteoarthritis index (WOMAC).
Results After 6 months, significant pain reduction was noted in the BMA group compared with the control group (p = 0.030). No significant differences were found in stiffness and physical activity scores between the groups. The intervention group demonstrated significant improvements in all assessed WOMAC subcategories pre- and posttreatment.
Conclusions Treatment with BMA can significantly reduce pain, potentially leading to improved knee functionality, suggesting its potential as a viable therapeutic option for managing knee OA.
Contribuições dos Autores
Cada autor contribuiu individual e significativamente para o desenvolvimento deste artigo: RC: conceptualização, aplicação da metodologia e escrita – rascunho. DMP: validação, visualização e escrita – rascunho original. MVAK: escrita – revisão e edição. TLVR: conceptualização e validação. RLO: conceptualização e validação. DAL: curadoria de dados, análise formal, escrita – revisão e edição.
Suporte Financeiro
Os autores declaram que não receberam suporte financeiro de agências dos setores público, privado ou sem fins lucrativos para a realização deste estudo.
Trabalho desenvolvido no Hospital Otavio de Freitas, Recife, PE, Brasil.
Publication History
Received: 21 June 2024
Accepted: 02 October 2024
Article published online:
14 June 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
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Renata Clazzer, Dilamar Moreira Pinto, Mariana Valois de Aquino Krause, Tale Lucas Vieira Rolim, Ricardo Lyra de Oliveira, Diego Ariel de Lima. Efeitos da infiltração intra-articular de aspirado de medula óssea no tratamento da osteoartrite de joelho: Estudo clínico comparando BMA versus corticosteroide e bloqueio genicular. Rev Bras Ortop (Sao Paulo) 2025; 60: s00451809512.
DOI: 10.1055/s-0045-1809512
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