40 years of CEPARM: transforming amyloidosis related to transthyretin from neglect to recognition

Abstract

Variant transthyretin amyloidosis with polyneuropathy (ATTRv-PN) and cardiomyopathy (ATTRv-CM), formerly known as familial amyloidotic polyneuropathy (FAP), is a severe, progressive disorder caused by mutations in the transthyretin (TTR) gene. Historically, FAP was considered a neglected disease due to its rarity and the limited understanding of its pathophysiology, which led to minimal research funding and few therapeutic options. The present article explores the transformative role of Centro de Paramiloidose Antônio Rodrigues de Mello (CEPARM), established in 1984, in elevating the status of FAP through significant advancements in research and treatment. Although CEPARM was not the sole catalyst for this shift, its contributions in liver transplantation, the development of pharmacological therapies, and holistic patient care have substantially improved the recognition and management of FAP. The article also examines CEPARM's impact on patient care, the ongoing challenges, and ethical considerations within the field.

Keywords

Amyloid Neuropathies, Familial - Prealbumin - Polyneuropathies - Cardiomyopathies - Liver Transplantation - Drug Therapy

Authors' Contributions

Conceptualization: MMG, MWC; Writing - review & editing: MMG, MWC.

Data Availability Statement

The contents are already available within the present article.

Editor-in-Chief: Hélio A. G. Teive 0000-0003-2305-1073.

Associate Editor: Eliasz Engelhardt 0000-0003-4168-1992.

Publikationsverlauf

Eingereicht: 19. November 2024

Angenommen: 03. April 2025

Artikel online veröffentlicht:
20. Juni 2025

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