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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2026; 36(02): 175-182
DOI: 10.1055/s-0045-1809318
Original Article

Diagnostic Value of Multiparametric Transrectal Ultrasound in Patients with Suspected Carcinoma of Prostate: A Tertiary Care Centre Experience

Authors

  • Prabhjyot Singh Chowhan

    1   Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Ujjwal Gorsi 

    1   Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Ravimohan Mavuduru

    2   Department of Urology, Advanced Urology Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Anupam Lal

    1   Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Uttam K. Mete

    2   Department of Urology, Advanced Urology Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India

  • Nandita Kakkar

    3   Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Abstract

Objectives

To establish the role of grayscale ultrasonography, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS) independently and in combination with multiparametric transrectal ultrasound (mp-TRUS) in detecting peripheral zone prostate cancer (PCa) and to compare the performance of mp-TRUS with multiparametric MRI (mp-MRI), keeping biopsy as the gold standard.

Materials and Methods

Thirty men with clinically suspected PCa were enrolled in this single-center-based prospective study conducted over a period of 1.5 years. All patients underwent mp-MRI, mp-TRUS, and guided biopsy. The mp-MRI and mp-TRUS were conducted and interpreted by two different observers who were blinded to each other's findings. In all patients, biopsy cores were taken from a minimum of 12 predetermined sites with extra cores taken from lesions suspicious on either grayscale ultrasonography, SWE, or CEUS.

Results

Malignancy was detected in 19 of our patients on mp-TRUS-guided biopsy. A total of 386 cores were obtained with a positive biopsy rate of 38%. mp-TRUS gave a sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 100, 63.63, 82.61, 100, and 86.67%, respectively, while the values for mp-MRI were 94.74, 45.45, 75.00, 83.33, and 76.67%, respectively. The area under the ROC curve for mp-TRUS was 0.818 ± 0.076. This value was higher than that for mp-MRI (0.701 ± 0.083).

Conclusion

Performance of mp-TRUS is comparable to that of mp-MRI in diagnosing peripheral zone PCa. By improving the diagnostic yield of grayscale ultrasonography, mp-TRUS also acts as a great guiding tool for targeted biopsies, especially in patients where no lesions are seen on grayscale imaging.

Keywords

prostatic neoplasms - multiparametric magnetic resonance imaging - biopsy - ultrasonography

Note

This work was previously presented at the ARRS 2021 Annual Conference.


Ethical Approval

Ethical approval was obtained from the Institutional Ethics Committee.


Patients' Consent

Written informed consent was obtained from all patients for this study.




Publication History

Article published online:
04 June 2025

© 2025. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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