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CC BY 4.0 · European Journal of General Dentistry
DOI: 10.1055/s-0045-1809300
Original Article

A Comparative Analysis of Effect of Statins in Cardiovascular Patients on Root Canal Calcification Using CBCT: A Retrospective Study

Neha Neha 
1   Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
,
Alpa Gupta 
1   Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
,
Dax Abraham 
1   Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
,
Lubna Ahmad 
1   Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
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Funding None.
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Abstract

Objective

Root canal calcification (RCC) occurs as a diffuse phenomenon, making endodontic treatment challenging. Various factors like systemic diseases and medication induce the calcification process. It has been stated in studies that statin causes odontoblastic differentiation of human dental pulp stem cells, causing RCC. The objective of the study was to evaluate and compare RCC in healthy individuals and cardiovascular patients with and without statin therapy using cone-beam computed tomography (CBCT).

Materials and Methods

This retrospective study comprises three groups in which group 1 consisted of healthy individuals, group 2 consisted of cardiovascular patients not taking statin medication, and group 3 consisted of cardiovascular patients taking statin medication. The study included healthy first or second mandibular molar. CBCT was utilized to detect the RCC in terms of volume measurement among all the groups.

Statistical Analysis

For inferential analysis, a one-way analysis of variance and post hoc Tukey's test will assess the significance of sample means against known values.

Results

The pairwise comparison revealed that there is no significant difference between group 1 and group 2, and comparatively, group 3 significantly has higher calcification (least volume) than groups 1 and 2 in both mandibular first and second molar.

Conclusion

Systemic medications like statin possess an increased risk of RCC due to odontoblastic differentiation of human dental pulp stem cells. CBCT should be employed as a diagnostic tool for accurate diagnosis of RCC and correlating systemic oral illness and facilitating early diagnosis.

Keywords

cardiovascular disease - cone-beam computed tomography - root canal calcification - statin

Ethical Approval

This cross-sectional study was approved by the Institutional Internal Ethical Committee (IEC) of the School of Dental Sciences, MRIIRS, Faridabad (letter no. MRIIRS/MRDC/SDS/IEC/2024/31 dated 18.06.2024).


Supplementary Material



Publication History

Article published online:
25 July 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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