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CC BY 4.0 · Eur J Dent
DOI: 10.1055/s-0045-1809184
Original Article

Correlation between Salivary Oxidative Stress Biomarkers and Clinical Severity of Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients

Nurina Febriyanti Ayuningtyas
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Fatimah Fauzi Basalamah
2   Oral Medicine Specialist Study Programme, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Gisela Lalita Brahmanikanya
2   Oral Medicine Specialist Study Programme, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Fatma Yasmin Mahdani 
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
2   Oral Medicine Specialist Study Programme, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Adiastuti Endah Parmadiati
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Desiana Radithia 
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Diah Savitri Ernawati
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
,
Madhu Shrestha
3   Department of Diagnostic Sciences, College of Dentistry, Texas A&M University, Dallas, Texas, United States
,
Ulinta Purwati Pasaribu
4   Department of Radiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
5   Medical Division of Radiation Oncology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
,
Satutya Wicaksono 
1   Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
› Institutsangaben
Funding We acknowledge and thank Universitas Airlangga under the scheme of International Research Collaboration Top #300 Number 422/UN3.LPPM/PT.01.03/2024 to fund this study and our patients who consented to participate.
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Abstract

Objective

Radiation-induced oral mucositis (RIOM) is the most common side effect of radiotherapy (RT) in head and neck cancer (HNC) patients. Oxidative stress plays a major role in the multistep pathogenesis of RIOM. However, the current understanding of the relationship between salivary biomarkers of oxidative stress and the clinical severity of RIOM remains limited. This study aims to analyze the correlation between salivary oxidative stress biomarkers and the clinical severity of RIOM.

Materials and Methods

This cross-sectional study analyzed the levels of salivary oxidative stress biomarkers from 25 HNC patients who underwent RT using enzyme-linked immunosorbent assay and the clinical grades of RIOM in the cohort. The data were then analyzed using the Spearman's correlation statistical test (p-value < 0.05).

Results

The findings demonstrated a significant correlation between salivary glutathione levels (r: –0.396; p: 0.050), superoxide dismutase levels (r: –0.447; p: 0.025), malondialdehyde levels (r: 0.479; p: 0.015), and lactate dehydrogenase levels (r: 0.460; p: 0.025) with the clinical severity of RIOM.

Conclusion

The higher salivary oxidative stress correlates with higher severity of RIOM.

Keywords

glutathione - superoxide dismutase - malondialdehyde - lactate dehydrogenase - oral mucositis - saliva - head and neck cancer - radiotherapy


Publikationsverlauf

Artikel online veröffentlicht:
27. Mai 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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