CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0045-1809149
Case Report and Review of Literature

Ewing's Sarcoma Omental Odyssey: Unraveling Rare Metastasis and Unforeseen Treatment Outcome on FDG PET/CT: Case Report with Review of Literature

1   Department of Nuclear Medicine, King George Medical University, Lucknow, Uttar Pradesh, India
,
Yogita Khandelwal
2   Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
,
Manish Ora
3   Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
,
Shivam Singh
1   Department of Nuclear Medicine, King George Medical University, Lucknow, Uttar Pradesh, India
› Institutsangaben
Funding None.

Abstract

Ewing's sarcoma is an uncommon and highly metastatic form of sarcoma affecting children and young adults, occurring in approximately 1 in 1.5 million individuals, with a predominance in males. We present an exceptionally unique case highlighting Ewing's sarcoma metastasis to the peritoneum and omentum, identified through an 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan and its unforeseen treatment response. In contrast to previously published literature concerning primary peritoneal primitive neuroectodermal tumors, this exceedingly notable instance illuminates the occurrence of metastatic Ewing's sarcoma within the peritoneum, as opposed to originating as a primary tumor within the peritoneum, revealing diagnostic intricacies. This case accentuates several pivotal learning points that enhance our understanding of Ewing's sarcoma. Also, the noteworthy high sensitivity and specificity of 18F-FDG PET/CT allow for early detection of recurrence and treatment response, substantially improving prognosis in Ewing's sarcoma patients, aiding in timely therapeutic interventions and optimizing patient outcomes.

Authors' Contributions

P.S. conceptualized and designed the study, Y.K. edited the manuscript editing, M.O. edited and revised the manuscript, and S.S. performed research and collected the literature.


Ethical Approval

This study received ethical approval from the Institutional Ethics Committee (IEC).


Patient's Consent

The authors confirm that all necessary patient consent forms have been obtained. The patient has provided written permission for their medical images and clinical details to be included in this publication. They have been informed that their identity will be protected by withholding their name and initials.




Publikationsverlauf

Artikel online veröffentlicht:
20. Mai 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Riggi N, Suvà ML, Stamenkovic I. Ewing's sarcoma. N Engl J Med 2021; 384 (02) 154-164
  • 2 Grünewald TGP, Cidre-Aranaz F, Surdez D. et al. Ewing sarcoma. Nat Rev Dis Primers 2018; 4 (01) 5
  • 3 Hawkins DS, Schuetze SM, Butrynski JE. et al. [18F]Fluorodeoxyglucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors. J Clin Oncol 2005; 23 (34) 8828-8834
  • 4 Koshkin VS, Bolejack V, Schwartz LH. et al. Assessment of imaging modalities and response metrics in Ewing sarcoma: correlation with survival. J Clin Oncol 2016; 34 (30) 3680-3685
  • 5 Hawkins DS, Rajendran JG, Conrad III EU, Bruckner JD, Eary JF. Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer 2002; 94 (12) 3277-3284
  • 6 Franzius C, Sciuk J, Brinkschmidt C, Jürgens H, Schober O. Evaluation of chemotherapy response in primary bone tumors with F-18 FDG positron emission tomography compared with histologically assessed tumor necrosis. Clin Nucl Med 2000; 25 (11) 874-881
  • 7 Völker T, Denecke T, Steffen I. et al. Positron emission tomography for staging of pediatric sarcoma patients: results of a prospective multicenter trial. J Clin Oncol 2007; 25 (34) 5435-5441
  • 8 Franzius C, Daldrup-Link HE, Sciuk J. et al. FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT. Ann Oncol 2001; 12 (04) 479-486
  • 9 Györke T, Zajic T, Lange A. et al. Impact of FDG PET for staging of Ewing sarcomas and primitive neuroectodermal tumours. Nucl Med Commun 2006; 27 (01) 17-24
  • 10 Kleis M, Daldrup-Link H, Matthay K. et al. Diagnostic value of PET/CT for the staging and restaging of pediatric tumors. Eur J Nucl Med Mol Imaging 2009; 36 (01) 23-36
  • 11 Rehman R, Osto M, Parry N. et al. Ewing sarcoma of the craniofacial bones: a qualitative systematic review. Otolaryngol Head Neck Surg 2022; 166 (04) 608-614
  • 12 Cotterill SJ, Ahrens S, Paulussen M. et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000; 18 (17) 3108-3114
  • 13 Cangir A, Vietti TJ, Gehan EA. et al. Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing's sarcoma studies. Cancer 1990; 66 (05) 887-893
  • 14 Geens L, Robays JV, Geert V, der Speeten KV. An unusual location of extraosseous Ewing's sarcoma. Case Rep Oncol 2013; 6 (02) 293-302
  • 15 Huh J, Kim KW, Park SJ. et al. Imaging features of primary tumors and metastatic patterns of the extraskeletal Ewing sarcoma family of tumors in adults: a 17-year experience at a single institution. Korean J Radiol 2015; 16 (04) 783-790
  • 16 Sharma P, Khangembam BC, Suman KCS. et al. Diagnostic accuracy of 18F-FDG PET/CT for detecting recurrence in patients with primary skeletal Ewing sarcoma. Eur J Nucl Med Mol Imaging 2013; 40 (07) 1036-1043
  • 17 Albano D, Dondi F, Schumacher RF. et al. Clinical and prognostic role of 18F-FDG PET/CT in pediatric Ewing sarcoma. J Pediatr Hematol Oncol 2020; 42 (02) e79-e86
  • 18 Tiwary A, Chauhan M, Jacob M. et al. Role of F-18 FDG PET/CT in response assessment of Ewing's sarcoma family of tumors. J Nucl Med 2012; 53 (Suppl. 01) 386
  • 19 Bakheet SM, Powe J, Kandil A, Ezzat A, Rostom A, Amartey J. F-18 FDG uptake in breast infection and inflammation. Clin Nucl Med 2000; 25 (02) 100-103
  • 20 Fisher D, Elwood K. Canadian Tuberculosis Standards. 7th ed.. Public Health Agency of Canada; 2013