Sleep Architecture, Muscle Function, and Daily Life Activities in Patients with Sarcopenia

Abstract

Objective

To examine associations between polysomnography, muscle mass and strength, and daily life activity index (DLAI) in patients with sarcopenia.

Materials and Methods

We measured polysomnography, muscle mass and strength, and DLAI in 16 patients with sarcopenia and 26 controls > 60 years old and then compared variables and correlations in the patients with sarcopenia.

Results

We found no differences in polysomnography between patients with sarcopenia and controls. Among patients with sarcopenia, latency to rapid eye-movement (REM) sleep was positively correlated with weight, REM %, and total sleep time was positively correlated with grip strength. Latency of REM sleep was negatively correlated with body mass index, NREM sleep, and apnea index was negatively correlated with grip strength. Daily life activity index correlated positively with grip strength.

Conclusion

Patients with sarcopenia showed significant correlations between polysomnography and weight, body mass index, and grip strength, suggesting a complex relationship involving sleep architecture, muscle function, and DLAI that deserves more research.

Keywords

sarcopenia - polysomnography - muscle mass - grip strength - daily life activities index

• References

• 1 Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T. et al; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48 (04) 601
• 2 Szlejf C, Suemoto CK, Drager LF, Griep RH, Fonseca MJM, Diniz MFHS. et al. Association of sleep disturbances with sarcopenia and its defining components: the ELSA-Brasil study. Braz J Med Biol Res 2021; 54 (12) e11539
• 3 Piovezan RD, Yu S, Hirotsu C, Marques-Vidal P, Haba-Rubio J, Tucker G. et al. Associations of indicators of sleep impairment and disorders with low muscle strength in middle-aged and older adults: The HypnoLaus cohort study. Maturitas 2022; 164: 52-59
• 4 Cacciatore S, Calvani R, Mancini J, Ciciarello F, Galluzzo V, Tosato M. et al; Lookup Study Group. Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8. Exp Gerontol 2025; 200: 112666
• 5 Dong X, He L, Zhang L, Shen Y. Association between sleep duration and sleep quality with pre-sarcopenia in the 20-59-year-old population: evidence from the National Health and Nutrition Examination Surveys 2005-2014. Arch Public Health 2024; 82 (01) 162
• 6 Chen L, Li Q, Huang X, Li Z. Association between sleep duration and possible sarcopenia in middle-aged and elderly Chinese individuals: evidence from the China health and retirement longitudinal study. BMC Geriatr 2024; 24 (01) 594
• 7 Beaudart C, Tilquin N, Abramowicz P, Baptista F, Peng DJ, Orlandi FdS. et al. Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data. Maturitas 2024; 180: 107902 PubMed
• 8 American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events. Rules, terminology and technical specifications. Version 2.0. 2012. Darien, IL: USA; 2012
• 9 Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged: the index of ADL a standardized measure of biological and psychosocial function. JAMA 1963; 185: 914-919
• 10 Cisterna B, Malatesta M. Molecular and structural alterations of skeletal muscle tissue nuclei during ageing. Int J Mol Sci 2024; 25 (03) 1833 PubMed
• 11 Frontera WR. Rehabilitation of older adults with sarcopenia: From cell to functioning. Prog Rehabil Med 2022; 7: 20220044
• 12 Tung H-T, Chen K-M, Chou C-P, Belcastro F, Hsu H-F, Kuo C-F. Acupunch exercise improved muscle mass, hand grip strength, and sleep quality of institutional older adults with probable sarcopenia. J Appl Gerontol 2023; 42 (05) 888-897
• 13 Aoyama S, Nakahata Y, Shinohara K. Chrono-nutrition has potential in preventing age-related muscle loss and dysfunction. Front Neurosci 2021; 15: 659883
• 14 Doza GL, Van Heden S, Felix FO, Singh V, Beaudart C. Impact of interventions on sarcopenia from the perspective of older persons: a systematic literature review. J Frailty Aging 2024; 13 (03) 224-232
• 15 Matsumoto T, Tanizawa K, Tachikawa R, Murase K, Minami T, Inouchi M. et al. Associations of obstructive sleep apnea with truncal skeletal muscle mass and density. Sci Rep 2018; 8 (01) 6550
• 16 Piovezan RD, Hirotsu C, Moizinho R, Souza HdS, D'Almeida V, Tufik S, Poyares D. Associations between sleep conditions and body composition states: results of the EPISONO study. J Cachexia Sarcopenia Muscle 2019; 10 (05) 962-973
• 17 Rogers MA, Evans WJ. Changes in skeletal muscle with aging: effects of exercise training. Exerc Sport Sci Rev 1993; 21: 65-102
• 18 Frischknecht R. Effect of training on muscle strength and motor function in the elderly. Reprod Nutr Dev 1998; 38 (02) 167-174
• 19 Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA. et al. Establishing the link between lean mass and grip strength cut points with mobility disability and other health outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci 2020; 75 (07) 1317-1323
• 20 Souza HdS, de Melo CM, Piovezan RD, Miranda REEPC, Carneiro-Junior MA, Silva BM. et al. Resistance training improves sleep and anti-inflammatory parameters in sarcopenic older adults: a randomized controlled trial. Int J Environ Res Public Health 2022; 19 (23) 16322