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DOI: 10.1055/s-0045-1807746
A Low-Grade Angiomyxofibromatous Tumor of the Falx Cerebelli: A Mimic of Fourth Ventricular Tumors
Abstract
Low-grade fibromyxoid tumors are very uncommon in children. A tumor of this type has never been reported in the posterior fossa to date. Such lesions may mimic more common lesions of the posterior fossa. Awareness of this entity and its subsequent behavior may guide better management and outcomes. We describe the case of a previously unreported low-grade angiomyxofibromatous tumor of the falx cerebelli in a 10-year-old female, whose presentation mimicked cystic lesions of the posterior fossa causing obstructive hydrocephalus. Microscopic examination revealed stellate cells set in myxoid and edematous stroma, along with a plexiform vasculature pattern. The tumor cells were diffusely immunopositive for vimentin and focally positive for S-100 protein, but negative for epithelial membrane antigen, CD34, MIC2, Bcl-2, glial fibrillary acidic protein, cytokeratin, CAM 5.2, desmin, and smooth muscle actin. This lesion could not be categorized according to the current World Health Organization classification of tumors of the nervous system. Therefore, there is a need for a better understanding of the central nervous system (CNS) myxoid neoplasms and a reassessment of the classification of CNS tumors.
Authors' Contributions
P.P.M. and P.P. conducted the literature review. The initial draft was prepared by V.R. and P.P., while P.P.M., V.R., and U.K. contributed to reviewing and editing the manuscript.
Publication History
Article published online:
26 May 2025
© 2025. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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