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CC BY 4.0 · Chinese medicine and natural products 2025; 05(01): e23-e29
DOI: 10.1055/s-0045-1807255
Review Article

Research Progress on the Role of Puerarin in the Prevention and Treatment of Alzheimer's Disease

Changsong Chu
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
,
Yaquan Jia
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
,
Yuan Liu
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
,
Ruofei Du
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
,
Zichuang Wang
3   School of Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Zhenqiang Zhang
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
,
Wanchun Zheng
3   School of Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Junying Song
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Henan Provincial Collaborative Innovation Center for Full Industry Chain Development of Chinese Medicine, Zhengzhou, Henan, China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (82274612), Key Research Project of the Henan Academy of Chinese Medical Sciences (2024Y1031), Henan Province Key Research and Development and Promotion Special Project (Science and Technology Research) (232102310505), Henan Province University Science and Technology Innovation Talents Program (23HASTIT044), and Henan University of Chinese Medicine Scientific Research Seedling Project (MP2023-08, MP2023-22).
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects cognitive abilities in the elderly. Puerarin plays an important role in the prevention and treatment of AD. It exerts potential therapeutic effects in multiple aspects, including regulating the expression of amyloid β-protein (Aβ), inhibiting abnormal phosphorylation of microtubule-associated protein-τ (Tau), scavenging free radicals, resisting oxidation, regulating metal metabolism to maintain cholinergic system stability, improving mitochondrial dysfunction, and resisting inflammation. However, the specific mechanisms by which puerarin protects cortical neurons in the brain are not fully explored. Hypothetical therapeutic pathways still require further scientific verification.

Keywords

alzheimer's disease - puerarin - dementia - cortical neurons

CRediT Authorship Contribution Statement

Changsong Chu: Project administration and validation. Yaquan Jia: Conceptualization, data curation, and writing—original draft. Yuan Liu: Data curation, methodology, and writing—review and editing. Ruofei Du: Data curation and software. Zichuang Wang: Methodology and writing—review and editing. Zhenqiang Zhang: Formal analysis and investigation. Wanchun Zheng: validation. Junying Song: Data curation.




Publication History

Received: 08 November 2024

Accepted: 12 January 2025

Article published online:
08 April 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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