Research Progress on the Role of Puerarin in the Prevention and Treatment of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects cognitive abilities in the elderly. Puerarin plays an important role in the prevention and treatment of AD. It exerts potential therapeutic effects in multiple aspects, including regulating the expression of amyloid β-protein (Aβ), inhibiting abnormal phosphorylation of microtubule-associated protein-τ (Tau), scavenging free radicals, resisting oxidation, regulating metal metabolism to maintain cholinergic system stability, improving mitochondrial dysfunction, and resisting inflammation. However, the specific mechanisms by which puerarin protects cortical neurons in the brain are not fully explored. Hypothetical therapeutic pathways still require further scientific verification.

Keywords

alzheimer's disease - puerarin - dementia - cortical neurons

CRediT Authorship Contribution Statement

Changsong Chu: Project administration and validation. Yaquan Jia: Conceptualization, data curation, and writing—original draft. Yuan Liu: Data curation, methodology, and writing—review and editing. Ruofei Du: Data curation and software. Zichuang Wang: Methodology and writing—review and editing. Zhenqiang Zhang: Formal analysis and investigation. Wanchun Zheng: validation. Junying Song: Data curation.

Publikationsverlauf

Eingereicht: 08. November 2024

Angenommen: 12. Januar 2025

Artikel online veröffentlicht:
08. April 2025

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