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CC BY 4.0 · Brazilian Journal of Oncology 2025; 21: s00451805099
DOI: 10.1055/s-0045-1805099
Original Article
Radiotherapy

Results of External Beam Parametrial Boost for Advanced Cervical Cancer

Geovanne Pedro Mauro 
1   Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
,
Gabriel Faria Najas 
2   Radiotherapy Division, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil
,
João Guilherme Eiras Poço 
2   Radiotherapy Division, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil
,
Rodolpho Truffa Kleine 
3   Gynecology Division, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil
,
Heloisa de Andrade Carvalho 
1   Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
› Institutsangaben Funding The authors declare that they did not receive funding from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

Introduction Even though largely used, external beam parametrial boost concurrent with brachytherapy for advanced cervical cancer is consensual and lacks prospective evidence.

Objective To assess the impact of external beam parametrial boost on cancer control and toxicity.

Materials and Methods The present research is a retrospective, single, institutional study of patients with locally advanced cervical cancer with parametrial involvement.

Results The charts of 247 patients with parametrial invasion treated with concurrent chemoradiation and brachytherapy were assessed. The mean follow-up was 48.2 months. Median overall survival (OS), local progression-free survival (LPFS), and distant progression-free survival (DPFS) were not reached. Overall survival, LPFS, and DPFS at 3 years were 81.4%, 87.4%, and 83.4%, respectively. The mean OS for patients receiving parametrial boost and those that did not receive was 47.4 months and 46.8 months, and the mean LPFS was 43.9 months and 44.0, respectively. There were no differences regarding acute (p = 0.662) or late (p = 0.923) toxicity between groups. There were 6 deaths due to treatment, all in the parametrial boost group.

Conclusion External beam parametrial boost should be carefully and not routinely considered. There is a lack of good evidence on the matter, and prospective studies should be designed regarding parametrial boost, perhaps with interstitial brachytherapy and not external beam.

Keywords

brachytherapy - radiotherapy - uterine cervical neoplasms

Ethics Committee Number

03582818.9.0000.0065.


Clinical Trials

None.




Publikationsverlauf

Eingereicht: 19. Juni 2024

Angenommen: 11. Dezember 2024

Artikel online veröffentlicht:
28. April 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
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Bibliographical Record
Geovanne Pedro Mauro, Gabriel Faria Najas, João Guilherme Eiras Poço, Rodolpho Truffa Kleine, Heloisa de Andrade Carvalho. Results of External Beam Parametrial Boost for Advanced Cervical Cancer. Brazilian Journal of Oncology 2025; 21: s00451805099.
DOI: 10.1055/s-0045-1805099
 

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