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CC BY 4.0 · World J Nucl Med 2025; 24(02): 185-188
DOI: 10.1055/s-0045-1805043
Case Report

Enhanced Detection of Recurrent Diffuse Malignant Peritoneal Mesothelioma Using 68Ga-FAPI PET/CT Compared to 18F-FDG PET/CT: A Case Report

Marwah Abdulrahman
1   Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Ula Al-Rasheed
1   Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Ali Dabous
3   Department of Transplant and Oncosurgery, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Akram Al-Ibraheem 
1   Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan
2   Department of Radiology and Nuclear Medicine, School of Medicine, the University of Jordan, Amman, Jordan
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Abstract

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and aggressive subtype of epithelioid mesothelioma that arises from the lining of the abdominal cavity. While the applications of traditional fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in diagnosis and staging of DMPM are well-established, the utility of gallium-68 fibroblast activating protein inhibitor (68Ga-FAPI) PET/CT in detecting disease recurrence remains an area that requires further research and validation, with limited literature. Implementing FAPI PET/CT for these cases may provide superior lesion detectability and higher reporter confidence, prompting the need for further studies to investigate the potential future role of FAPI theranostics in guiding treatment decisions for DMPM. This case report describes a 49-year-old male patient diagnosed with DMPM, who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy but developed recurrent disease that was better visualized on 68Ga-FAPI PET/CT compared with 18F-FDG PET/CT.

Keywords

FAPI - DMPM - malignant peritoneal mesothelioma - 68Ga-FAPI PET/CT - FAPI theranostics

Ethical Consideration

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the Helsinki Declaration as revised in 2013 and its later amendments or comparable ethical standards.


Authors' Contributions

All authors have contributed in writing the manuscript and collecting the required materials.


M.A.: Managed the patient's care, collected the clinical data along with the figures, and wrote the initial draft of the case report.


U.A.-R.: Reviewed the clinical data and edited the manuscript.


A.D.: Assisted in giving all the required information regarding patient's performed surgeries and revised the written data.


A.A.-I.: Supervised the patient's care, reviewed the manuscript for clinical accuracy, and approved the final version.


All authors: Reviewed the results and approved the final version of the manuscript.




Publikationsverlauf

Artikel online veröffentlicht:
12. März 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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