Subscribe to RSS
Download PDF
DOI: 10.1055/s-0045-1804883
A Rare Case of Intracranial Metastasis of Chondroblastic Osteosarcoma from Lungs: A Case Report and Review of Literature
Abstract
Osteosarcoma are the most common primary bone tumors in children and adolescents. Brain metastases of osteosarcoma is usually a terminal event in the disease course. Surgical resection of the brain metastatic lesion forms the mainstay of treatment with chemotherapy and radiotherapy as add-ons. We present the case of a 57-year-old woman who presented with complains of breathlessness and headache. Contrast-enhance computed tomography (CECT) showed a large left lung mass. Magnetic resonance imaging (MRI) of the brain depicted an anterior temporal space occupying lesion. The patient underwent surgical removal of the mass lesion, with biopsy revealing the diagnosis as chondroblastic osteosarcoma.
Ethical Approval Statement
All procedures in this study were performed in accordance with the ethical standards of the institution, based on the 1964 Declaration of Helsinki and its later amendments.
Publication History
Article published online:
21 May 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Link MP, Gebhardt MC, Meyers PA. Osteosarcoma. In: Pizzo PA, Poplack DG. eds Principles & Practice of Paediatric Oncology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005: 1075-1113
- 2 Wagner MS, Reyes CV. Primary chondroblastic osteosarcoma of the lung. Sarcoma 1999; 3 (3–4): 193-195
- 3 Miller DL, Allen MS. Rare pulmonary neoplasms. Mayo Clin Proc 1993; 68 (05) 492-498
- 4 Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J Neurooncol 2005; 75 (01) 5-14
- 5 Nayak L, Lee EQ, Wen PY. Epidemiology of brain metastases. Curr Oncol Rep 2012; 14 (01) 48-54
- 6 Salvati M, D'Elia A, Frati A, Santoro A. Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience. J Neurooncol 2010; 98 (03) 373-377
- 7 Postovsky S, Ash S, Ramu IN. et al. Central nervous system involvement in children with sarcoma. Oncology 2003; 65 (02) 118-124
- 8 Rabah F, Al-Mashaikhi N, Beshlawi I. et al. Brain is not always the last fortress; osteosarcoma with large brain metastasis. J Pediatr Hematol Oncol 2013; 35 (02) e91-e93
- 9 Doval DC, Chacko M, Sinha R. et al. A rare case of brain metastasis in a patient with osteosarcoma. South Asian J Cancer 2017; 6 (01) 36-37
- 10 Soto JM, Reed LK, Benardete EA. Successful endovascular removal of a chondroblastic osteosarcoma embolus within the left middle cerebral artery. Proc Bayl Univ Med Cent 2020; 33 (03) 451-452
- 11 Chang JW, Howng SL, Sun ZM, Kuo TH, Duh CC. An unusual intracranial metastasis of osteosarcoma. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1994; 10 (12) 700-704
- 12 Galicich JH, Sundaresan N, Arbit E, Passe S. . Surgical treatment of single brain metastases: factor associated with survival. Cancer 1980; 45 (02) 381-386
- 13 Huang W, Deng HY, Li D. et al. Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis. J Cardiothorac Surg 2022; 17 (01) 240
- 14 VandenBussche CJ, Sathiyamoorthy S, Wakely Jr PE, Ali SZ. Chondroblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on FNA. Cancer Cytopathol 2016; 124 (07) 493-500