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CC BY-NC-ND 4.0 · Sleep Sci
DOI: 10.1055/s-0045-1802967
Original Article

Feasibility of High-Resolution Oximeter Plus Actigraphy Combined with a Cloud-Based Algorithm for the Detection of Obstructive Sleep Apnea in Children with Craniofacial Anomalies

Sergio Henrique Kiemle Trindade 
1   Sleep Studies Unit, Laboratory of Physiology, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
2   Faculdade de Medicina de Bauru, Universidade de São Paulo (FMBRU-USP), Bauru, SP, Brazil
3   Department of Otorhinolaryngology, Hospital de Reabilitação de Anomalias Craniofaciais (HRAC), Universidade de São Paulo (USP), Bauru, SP, Brazil
,
Fábio Luiz Banhara 
1   Sleep Studies Unit, Laboratory of Physiology, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
,
Leide Vilma Fidélis da Silva
1   Sleep Studies Unit, Laboratory of Physiology, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
,
Sara Quaglia de Campos Giampá 
4   Laboratory of Medical Research on Sleep (LIM/63), Division of Pulmonology, Department of Cardiopulmonology, Instituto do Coração (InCor), Hospital das Clínicas, Faculty of Medicine, Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil
,
Lais Mota Furtado Sena
3   Department of Otorhinolaryngology, Hospital de Reabilitação de Anomalias Craniofaciais (HRAC), Universidade de São Paulo (USP), Bauru, SP, Brazil
,
Ivy Kiemle Trindade-Suedam 
1   Sleep Studies Unit, Laboratory of Physiology, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, SP, Brazil
5   Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru SP, Brazil
› Institutsangaben
Funding Source The authors declare that they did not receive funding from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

Objective

To verify the feasibility of high-resolution oximeter plus actigraphy combined with a cloud-based algorithm for the detection of obstructive sleep apnea (OSA) in children with craniofacial anomalies.

Materials and Methods

In the present prospective, cross-sectional study, we evaluated children previously submitted to primary surgical palate repair with a genetically confirmed diagnosis of Treacher Collins syndrome (TCS), non-syndromic Robin sequence (NSRS), or non-syndromic cleft palate (NSCP). The children underwent a clinical evaluation, had their anthropometric measures taken, and were submitted to OSA detection using high-resolution oximeter plus actigraphy combined with a cloud-based algorithm (Biologix Sleep Test, Biologix Sistemas S.A., São Paulo, SP, Brazil).

Results

In total, 64 children (TCS: n = 16; NSRS: n = 29; NSCP: n = 19) were included in the final analysis (mean age: 10 ± 2 years; 64% of female patients). The Biologix Sleep Test showed that 59 patients (92%) presented OSA according to the oxygen desaturation index (ODI): 36 (56%) were diagnosed with mild OSA, 19 (30%), with moderate OSA, and 4 (6%), with severe OSA. The high-resolution oximeter recording showed excellent signal quality in 94.53 ± 5.29% of the exams, with a success rate of exams on the first night of 90%. No significant difference was found in terms of ODI among the subgroups (p > 0.05). A significant relationship was observed between increased ODI with greater hypoxic burden and lower estimated sleep efficiency. The multiple linear regression analysis demonstrated a significant association between changes in total ODI with lower estimated sleep efficiency and sleep ODI.

Conclusion

High-resolution oximeter plus actigraphy combined with a cloud-based algorithm demonstrated adequate feasibility and applicability for OSA detection in children with craniofacial anomalies.

Keywords

oximetry - actigraphy - sleep apnea - obstructive - Treacher Collins syndrome - Pierre Robin syndrome


Publikationsverlauf

Eingereicht: 11. Oktober 2024

Angenommen: 06. Januar 2025

Artikel online veröffentlicht:
27. März 2025

© 2025. Brazilian Sleep Academy. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Bibliographical Record
Sergio Henrique Kiemle Trindade, Fábio Luiz Banhara, Leide Vilma Fidélis da Silva, Sara Quaglia de Campos Giampá, Lais Mota Furtado Sena, Ivy Kiemle Trindade-Suedam. Feasibility of High-Resolution Oximeter Plus Actigraphy Combined with a Cloud-Based Algorithm for the Detection of Obstructive Sleep Apnea in Children with Craniofacial Anomalies. Sleep Sci ; : s00451802967.
DOI: 10.1055/s-0045-1802967