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DOI: 10.1055/s-0045-1802574
Regionalization of Health Care in Head and Neck Cancer: Concept and Considerations
Funding The authors declare that they have received funding from Agencia Nacional de Investigación y Desarrollo and from Fondo Nacional de Desarrollo Científico y Tecnológico (FONIS SAI21|0003) to conduct the present study.

Abstract
Introduction
Head and neck cancer are rare and require complex medical and surgical management. Regionalization or centralization of care, defined as the concentration of patients with complex diseases from a specific area in institutions with more experienced and highly functional multidisciplinary teams, may be an alternative to achieve better oncologic outcomes.
Objective
To systematize the current knowledge regarding the centralization of care in head and neck oncology and its consequences in the practice of related surgeries.
Data Synthesis
Currently, there is evidence that this strategy shows better oncologic outcomes in centers with greater volumes, greater adherence to evidence-based clinical guidelines and quality indicators, and a multidisciplinary team in charge of decision-making. The center in Ontario, Canada, is framed as an example of this strategy, achieving improved outcomes while maintaining a high level of quality.
Conclusion
Although more high-quality studies are needed to support this strategy, we believe that the evidence already available is sufficient to consider it a valid option to improve the oncologic outcomes of patients.
Keywords
squamous cell carcinoma of head and neck - quality indicators - health care - patient care teamPublikationsverlauf
Eingereicht: 28. August 2023
Angenommen: 18. November 2024
Artikel online veröffentlicht:
20. August 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Sebastián Castro, Mario Tapia, Felipe Cardemil. Regionalization of Health Care in Head and Neck Cancer: Concept and Considerations. Int Arch Otorhinolaryngol 2025; 29: s00451802574.
DOI: 10.1055/s-0045-1802574
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References
- 1 Sung H, Ferlay J, Siegel RL. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71 (03) 209-249 https://pubmed.ncbi.nlm.nih.gov/33538338/ cited 2023Dec27 [Internet]
- 2 Sullivan T, Irish J. Building the Ontario Surgical Oncology Program. https://doi.org/101177/0840470417729171 [Internet]. 2017 Dec 12 [cited 2023 Dec 27];31(1):22–5. Available from: https://journals.sagepub.com/doi/10.1177/0840470417729171
- 3 Disparities in care point to need for complex cancer surgical centres – Canadian Partnership Against Cancer [Internet]. [cited 2023 Dec 27]. Available from: https://www.partnershipagainstcancer.ca/news-events/news/article/disparities-in-care-point-to-need-for-complex-cancer-surgical-centres/
- 4 Hollenbeck BK, Miller DC, Wei JT, Montie JE. Regionalization of care: centralizing complex surgical procedures. Nat Clin Pract Urol 2005; 2 (10) 461 https://pubmed.ncbi.nlm.nih.gov/16474601/ cited 2023Dec27 [Internet]
- 5 Orlandi E, Alfieri S, Simon C, Trama A, Licitra L. RARECAREnet Working Group. Treatment challenges in and outside a network setting: Head and neck cancers. Eur J Surg Oncol 2019; 45 (01) 40-45 https://pubmed.ncbi.nlm.nih.gov/29478741/ cited 2023 Dec 27 [Internet]
- 6 James N, Hartley A. Improving outcomes in head and neck cancer. Clin Oncol (R Coll Radiol) 2003; 15 (05) 264-265 https://pubmed.ncbi.nlm.nih.gov/12924457/ cited 2023 Dec 27 [Internet]
- 7 Friedland PL, Bozic B, Dewar J, Kuan R, Meyer C, Phillips M. Impact of multidisciplinary team management in head and neck cancer patients. Br J Cancer 2011; 104 (08) 1246-1248 https://pubmed.ncbi.nlm.nih.gov/21448166/ cited 2023 Dec 27 [Internet]
- 8 Tsai WC, Kung PT, Wang ST, Huang KH, Liu SA. Beneficial impact of multidisciplinary team management on the survival in different stages of oral cavity cancer patients: results of a nationwide cohort study in Taiwan. Oral Oncol 2015; 51 (02) 105-111 https://pubmed.ncbi.nlm.nih.gov/25484134/ cited 2023 Dec 27 [Internet]
- 9 Birkmeyer JD, Siewers AE, Finlayson EVA. et al. Hospital volume and surgical mortality in the United States. N Engl J Med 2002; 346 (15) 1128-1137 https://pubmed.ncbi.nlm.nih.gov/11948273/ cited 2023 Dec 27 [Internet]
- 10 Eskander A, Irish J, Groome PA. et al. Volume-outcome relationships for head and neck cancer surgery in a universal health care system. Laryngoscope 2014; 124 (09) 2081-2088 https://pubmed.ncbi.nlm.nih.gov/24706437/ cited 2023 Dec 27 [Internet]
- 11 Eskander A, Merdad M, Irish JC. et al. Volume-outcome associations in head and neck cancer treatment: a systematic review and meta-analysis. Head Neck 2014; 36 (12) 1820-1834 https://pubmed.ncbi.nlm.nih.gov/24123512/ cited 2023 Dec 27 [Internet]
- 12 Eskander A, Goldstein DP, Irish JC. Health Services Research and Regionalization of Care-From Policy to Practice: the Ontario Experience in Head and Neck Cancer. Curr Oncol Rep 2016; 18 (03) 19 https://pubmed.ncbi.nlm.nih.gov/26869188/ cited 2023 Dec 27 [Internet]
- 13 Donahedian. La definición de calidad y enfoques para su evaluación. Vol 1. Exploraciones en Evaluación y Monitoreo de la Calidad. Health Administration Press: 2017;1(ISBN: 9780914904489.):1988
- 14 Chen AY. Quality initiatives in head and neck cancer. Curr Oncol Rep 2010; 12 (02) 109-114 https://pubmed.ncbi.nlm.nih.gov/20425595/ cited 2023 Dec 27 [Internet]
- 15 Takes RP, Halmos GB, Ridge JA. et al. Value and Quality of Care in Head and Neck Oncology. Curr Oncol Rep 2020; 22 (09) 92 . Available from: /pmc/articles/PMC7351804/
- 16 Bergamini C, Locati L, Bossi P. et al. Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?. Oral Oncol 2016; 54: 54-57 https://pubmed.ncbi.nlm.nih.gov/26774920/ cited 2023 Dec 27 [Internet]
- 17 Liu JC, Kaplon A, Blackman E, Miyamoto C, Savior D, Ragin C. The impact of the multidisciplinary tumor board on head and neck cancer outcomes. Laryngoscope 2020; 130 (04) 946-950 . Available from: /pmc/articles/PMC7868105/
- 18 Trama A, Botta L, Foschi R. et al. Quality of Care Indicators for Head and Neck Cancers: The Experience of the European Project RARECAREnet. Front Oncol 2019; 9: 837 . Available from: /pmc/articles/PMC6722861/
- 19 van Overveld LFJ, Braspenning JCC, Hermens RPMG. Quality indicators of integrated care for patients with head and neck cancer. Clin Otolaryngol 2017; 42 (02) 322-329 https://pubmed.ncbi.nlm.nih.gov/27537106/ cited 2023 Dec 27 [Internet]
- 20 Cramer JD, Speedy SE, Ferris RL, Rademaker AW, Patel UA, Samant S. National evaluation of multidisciplinary quality metrics for head and neck cancer. Cancer 2017; 123 (22) 4372-4381 https://pubmed.ncbi.nlm.nih.gov/28727137/ cited 2023 Dec 27 [Internet]
- 21 Gourin CG, Starmer HM, Herbert RJ. et al. Quality of care and short- and long-term outcomes of laryngeal cancer care in the elderly. Laryngoscope 2015; 125 (10) 2323-2329 https://pubmed.ncbi.nlm.nih.gov/26010671/ cited 2023 Dec 27 [Internet]
- 22 Langton S, Siau D, Bankhead C. Two-week rule in head and neck cancer 2000-14: a systematic review. Br J Oral Maxillofac Surg 2016; 54 (02) 120-131 https://pubmed.ncbi.nlm.nih.gov/26795572/ cited 2023 Dec 27 [Internet]
- 23 Murphy CT, Galloway TJ, Handorf EA. et al. Survival Impact of Increasing Time to Treatment Initiation for Patients With Head and Neck Cancer in the United States. J Clin Oncol 2016; 34 (02) 169-178 . Available from: /pmc/articles/PMC4858932/
- 24 Graboyes EM, Kompelli AR, Neskey DM. et al. Association of Treatment Delays With Survival for Patients With Head and Neck Cancer: A Systematic Review. JAMA Otolaryngol Head Neck Surg 2019; 145 (02) 166-177 https://pubmed.ncbi.nlm.nih.gov/30383146/ cited 2023 Dec 27 [Internet]
- 25 Goel AN, Frangos MI, Raghavan G. et al. The impact of treatment package time on survival in surgically managed head and neck cancer in the United States. Oral Oncol 2019; 88: 39-48 https://pubmed.ncbi.nlm.nih.gov/30616795/ cited 2023 Dec 27 [Internet]
- 26 Eskander A, Kang SY, Tweel B. et al. Quality Indicators: Measurement and Predictors in Head and Neck Cancer Free Flap Patients. Otolaryngol Head Neck Surg 2018; 158 (02) 265-272 https://pubmed.ncbi.nlm.nih.gov/29293404/ cited 2023 Dec 27 [Internet]
- 27 Jha AK, Larizgoitia I, Audera-Lopez C, Prasopa-Plaizier N, Waters H, Bates DW. The global burden of unsafe medical care: analytic modelling of observational studies. BMJ Qual Saf 2013; 22 (10) 809-815 https://pubmed.ncbi.nlm.nih.gov/24048616/ cited 2023 Dec 27 [Internet]
- 28 Hall BL, Hamilton BH, Richards K, Bilimoria KY, Cohen ME, Ko CY. Does surgical quality improve in the American College of Surgeons National Surgical Quality Improvement Program: an evaluation of all participating hospitals. Ann Surg 2009; 250 (03) 363-376 https://pubmed.ncbi.nlm.nih.gov/19644350/ cited 2023 Dec 27 [Internet]
- 29 The development of quality of care measures for oral cavity cancer. Arch Otolaryngol Head Neck Surg 2008; 134 (06) 672 https://pubmed.ncbi.nlm.nih.gov/18559740/ cited 2023 Dec 27 [Internet]
- 30 Chen MM, Megwalu UC, Liew J, Sirjani D, Rosenthal EL, Divi V. Regionalization of head and neck cancer surgery may fragment care and impact overall survival. Laryngoscope 2019; 129 (06) 1413-1419 https://pubmed.ncbi.nlm.nih.gov/30152007/ cited 2023 Dec 27 [Internet]
- 31 Roman BR, Awad MI, Patel SG. Defining value-driven care in head and neck oncology. Curr Oncol Rep 2015; 17 (01) 424 https://pubmed.ncbi.nlm.nih.gov/25416318/ cited 2023 Dec 27 [Internet]
- 32 Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L. EUROCARE Working Group. Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study. Eur J Cancer 2015; 51 (15) 2130-2143 https://pubmed.ncbi.nlm.nih.gov/26421817/ cited 2023 Dec 28 [Internet]
- 33 ICES | Head and Neck Cancer Surgery in Ontario, 2003-2010: An ICES Atlas [Internet]. [cited 2023 Dec 27]. Available from: https://www.ices.on.ca/publications/atlases/head-and-neck-cancer-surgery-in-ontario-2003%E2%80%922010-an-ices-atlas/