CC BY-NC-ND 4.0 · South Asian J Cancer 2024; 13(04): 236-240
DOI: 10.1055/s-0045-1802336
Review Article
Diagnosis

CT and MR Imaging in Colorectal Carcinoma: A Tool for Diagnosis, Staging, Response Evaluation, and Follow-Up

Samarjit Singh Ghuman
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Rohit Kochhar
2   Department of Radiology, The Christie NHS Foundation Trust, United Kingdom
,
Harsh Mahajan
3   Department of Nuclear Medicine and PET CT, Sir Ganga Ram Hospital, New Delhi, India
,
T.B.S. Buxi
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Arun Gupta
4   Department of Interventional Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Anil Arora
5   Department of Surgical Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
K.K. Saxena
6   Department of Oncology, Sant Parmanand Hospital, Delhi, India
,
Seema Sud
7   Department of Radiology, CT Scan and MRI, Sir Ganga Ram Hospital, New Delhi, India
,
Aditi Sud
7   Department of Radiology, CT Scan and MRI, Sir Ganga Ram Hospital, New Delhi, India
,
Kishan Rawat
7   Department of Radiology, CT Scan and MRI, Sir Ganga Ram Hospital, New Delhi, India
,
Munish K. Sachdeva
5   Department of Surgical Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Ajit Yadav
4   Department of Interventional Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Saumitra Rawat
5   Department of Surgical Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Shyam Aggarwal
8   Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India
,
Purvish M. Parikh
9   Department of Clinical Hematology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
,
C. Selvasekar
10   Clinical Services and Specialist Surgery, The Christie NHS Foundation Trust, Manchester, United Kingdom
› Author Affiliations
Funding None.

Abstract

The present review highlights the role of computed tomography (CT), CT colonography (CTC), and magnetic resonance imaging (MRI) in the diagnosis, staging, response evaluation, and follow-up of colorectal cancer. For a CT scan, prior bowel preparation is required. This is done to enhance imaging of the colon with the use of oral or rectal contrast agents. Negative contrast like air or carbon dioxide are helpful in detecting polyps and masses by distending the colon. Virtual colonoscopy offers a lower-radiation alternative for polyp and cancer detection. Intravenous contrast administration with arterial and venous phase CT images is also important in complete staging of a known case of colon cancer and for evaluation of residual/recurrent disease. With respect to MRI, high-resolution T2-weighted images in multiple planes are important, with diffusion-weighted imaging (DWI) sequences being important for restaging. Intravenous contrast is not generally recommended. Contrast-enhanced CT and MRI are used for nodal and distant metastasis staging, with special attention to the pelvic side wall nodes. Positron emission tomography (PET) CT is to be considered for further evaluation if the findings are unclear and recurrence is suspected.



Publication History

Article published online:
24 January 2025

© 2025. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Roland CL, Barnett CC. Colorectal polyps. In: Harken AH, Moore EE. eds. Abernathy's Surgical Secrets. 6th ed.. St. Louis, MO: Mosby; 2009: 258-261
  • 2 Parikh PM, Sahoo TP, Biswas G. et al. Practical consensus guidelines for the use of S-1 in GI malignancies. South Asian J Cancer 2024; 13 (01) 77-82
  • 3 Hari A, Jinto EG, Dennis D. et al. Choice of baseline hazards in joint modeling of longitudinal and time-to-event cancer survival data. Stat Appl Genet Mol Biol 2024; 23 (01) 20230038
  • 4 Pickhardt PJ, Hassan C, Halligan S, Marmo R. Colorectal cancer: CT colonography and colonoscopy for detection: systematic review and meta-analysis. Radiology 2011; 259 (02) 393-405
  • 5 Theis J, Kim DH, Lubner MG, Muñoz del Rio A, Pickhardt PJ. CT colonography after incomplete optical colonoscopy: bowel preparation quality at same-day vs. deferred examination. Abdom Radiol (NY) 2016; 41 (01) 10-18
  • 6 Sha J, Chen J, Lv X, Liu S, Chen R, Zhang Z. Computed tomography colonography versus colonoscopy for detection of colorectal cancer: a diagnostic performance study. BMC Med Imaging 2020; 20 (01) 51
  • 7 Pickhardt PJ. Positive oral contrast material for abdominal CT: current clinical indications and areas of controversy. AJR Am J Roentgenol 2020; 215 (01) 69-78
  • 8 Hamlin DJ, Burgener FA. Positive and negative contrast agents in CT evaluation of the abdomen and pelvis. J Comput Tomogr 1981; 5 (02) 82-90
  • 9 Arya S, Das D, Engineer R, Saklani A. Imaging in rectal cancer with emphasis on local staging with MRI. Indian J Radiol Imaging 2015; 25 (02) 148-161
  • 10 Amin MB, Greene FL, Edge SB. et al. The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin 2017; 67 (02) 93-99
  • 11 Singla SC, Kaushal D, Sagoo HS, Calton N. Comparative analysis of colorectal carcinoma staging using operative, histopathology and computed tomography findings. Int J Appl Basic Med Res 2017; 7 (01) 10-14
  • 12 Hennig J. An evolution of low-field strength MRI. Magn Reson Mater Biol Phys Med 2023; 36 (03) 335-346
  • 13 van de Velde CJ, Boelens PG, Tanis PJ. et al. Experts reviews of the multidisciplinary consensus conference colon and rectal cancer 2012: science, opinions and experiences from the experts of surgery. Eur J Surg Oncol 2014; 40 (04) 454-468
  • 14 Yang X, Chen Y, Wen Z. et al. Role of quantitative dynamic contrast-enhanced MRI in evaluating regional lymph nodes with a short-axis diameter of less than 5 mm in rectal cancer. AJR Am J Roentgenol 2019; 212 (01) 77-83
  • 15 Hsu WC, Huang PC, Pan KT. et al. Predictors of invasive adenocarcinomas among pure ground-glass nodules less than 2 cm in diameter. Cancers (Basel) 2021; 13 (16) 3945
  • 16 Stewart CL, Warner S, Ito K. et al. Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?. Curr Probl Surg 2018; 55 (09) 330-379
  • 17 Acciuffi S, Meyer F, Bauschke A, Croner R, Settmacher U, Altendorf-Hofmann A. Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors. J Cancer Res Clin Oncol 2022; 148 (03) 657-665
  • 18 Uribe PM, Hudson AM, Lockard G. et al. Hepatocyte growth factor mimetic confers protection from aminoglycoside-induced hair cell death in vitro. Hear Res 2023; 434: 108786
  • 19 Renehan AG, Malcomson L, Emsley R. et al. Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis. Lancet Oncol 2016; 17 (02) 174-183
  • 20 Erber BM, Reidler P, Goller SS. et al. Impact of dynamic contrast enhanced and diffusion-weighted MR imaging on detection of early local recurrence of soft tissue sarcoma. J Magn Reson Imaging 2023; 57 (02) 622-630
  • 21 Unterrainer M, Deroose CM, Herrmann K. et al; European Organisation for Research and Treatment of Cancer (EORTC) Imaging Group. Electronic address: https://twitter.com/@EORTC, European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group, European Society of Oncologic Imaging (ESOI) and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). Imaging standardisation in metastatic colorectal cancer: a joint EORTC-ESOI-ESGAR expert consensus recommendation. Eur J Cancer 2022; 176: 193-206
  • 22 Achilli P, Magistro C, Abd El Aziz MA. et al. Modest agreement between magnetic resonance and pathological tumor regression after neoadjuvant therapy for rectal cancer in the real world. Int J Cancer 2022; 151 (01) 120-127
  • 23 Kershaw L, Forker L, Roberts D. et al. Feasibility of a multiparametric MRI protocol for imaging biomarkers associated with neoadjuvant radiotherapy for soft tissue sarcoma. BJR Open 2021; 3 (01) 20200061
  • 24 Dawood ZS, Hamad A, Moazzam Z. et al. Colonoscopy, imaging, and carcinoembryonic antigen: comparison of guideline adherence to surveillance strategies in patients who underwent resection of colorectal cancer. A systematic review and meta-analysis. Surg Oncol 2023; 47: 101910