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CC BY 4.0 · Journal of Coloproctology 2025; 45(04): s00451801891
DOI: 10.1055/s-0045-1801891
Case Report

Complete Response with Modified FLOX in Metastatic Colon Cancer: A Case Report

Authors

  • Denis Artico Galhera 

    1   Department of Oncology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP), Hospital das Clínicas, School of Medicine, Universidade de São Paulo (HCFMUSP), SP, Brazil

  • Camila Motta Venchiarutti Moniz 

    1   Department of Oncology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP), Hospital das Clínicas, School of Medicine, Universidade de São Paulo (HCFMUSP), SP, Brazil

Funding The authors declare that they did not receive funding from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

Introduction

Colorectal cancer (CRC) is one of the main causes of death by cancer. Patients diagnosed with colon adenocarcinoma and unresectable liver metastases have a poor prognosis, with a median overall survival (OS) of 24 months.

Case Presentation

We herein report the case of a 7-year sustained complete response (CR) with 2 cycles of modified 5-fluorouracil plus oxaliplatin (mFLOX) in a metastatic setting. The patient is a White Brazilian male aged 59 years.

Conclusion

There is scarce evidence on the clinical evolution of non-operable patients with metastasis to establish a definitive cure only with a chemotherapy regimen, without complimentary liver resection. The patient herein reported achieved CR with only two cycles of treatment, which is not usual in this scenario. He was deemed non-operable because of the number and position of the lesions detected before the start of chemotherapy.

Keywords

colorectal cancer - fluorouracil - oxaliplatin - complete response

Ethical Approval and Consent to Participate

The present study was approved by the institutional Ethics in Research Committee, and the patient signed the informed consent form.


Consent for Publication

The patient consented to the publication and signed the informed consent form.


Authors' Contributions

CMVM: conceptualization and writing – review & editing; and DAG: writing – original draft. Both authors approved the final manuscript.




Publication History

Received: 04 October 2024

Accepted: 29 October 2024

Article published online:
29 December 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Denis Artico Galhera, Camila Motta Venchiarutti Moniz. Complete Response with Modified FLOX in Metastatic Colon Cancer: A Case Report. Journal of Coloproctology 2025; 45: s00451801891.
DOI: 10.1055/s-0045-1801891