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DOI: 10.1055/s-0044-1801320
Association Between the Expression of Cytochrome P450 and Glutathione S-transferase Enzyme and Antrochoanal Polyp Pathogenesis
Funding The authors declare that they did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study.
Abstract
Introduction Antrochoanal polyp, which is a kind of smooth-surfaced single nasal polyp, is commonly present in cases of nasal obstruction. The pathogenesis of polyp formation is still unclear, but allergy is supposed to be a cause.
Objectives To investigate the expression levels of antioxidant enzymes in antrochoanal polyp tissue.
Methods The antrochoanal polyp group was composed of 23 patients who were diagnosed microscopically, and the control group was composed of 38 healthy patients. The sample of the control group was taken from the inferior turbinate mucosa by punch biopsy under general anesthesia, and the antrochoanal polyp sample was collected from sinus surgery. The cytochrome P450 (CYP) and glutathione S-transferase (GST) expressions of the groups were investigated under microscopy and scored by senior pathologists.
Results The antrochoanal polyp group had statistically less expression of CYP family 1 subfamily A member 1 (CYP1A1) than the control group (p < 0.05). Moreover, GST Pi 1 (GSTP1), GST Mu 1 (GSTM1), and GST Alpha 1 (GSTA1) expressions were not different between the groups (p > 0.05).
Conclusion Allergy and chronic inflammation are postulated reasons for antrochoanal polyp formation, but, according to our results, we could not detect any relation between antrochoanal polyp formation and GST expression in tissue. However, the decreased level of CYP1A1 expression in the antrochoanal polyp group may be related with the pathogenesis of the antrochoanal polyp formation.
Ethical Approval and Consent to Participate
The current study was conducted according to the rules of the institutional ethics committee. Informed consent was obtained from each participant.
Authors' Contributions
All authors: study design, data analysis, data collection, statistical analyses, and writing and drafting the article
Publikationsverlauf
Eingereicht: 02. November 2023
Angenommen: 09. Oktober 2024
Artikel online veröffentlicht:
29. Mai 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
Mehmet Gökhan Demir, Sedat Aydın, Serpil Oguztuzun, Kayhan Basak. Association Between the Expression of Cytochrome P450 and Glutathione S-transferase Enzyme and Antrochoanal Polyp Pathogenesis. Int Arch Otorhinolaryngol 2025; 29: s00441801320.
DOI: 10.1055/s-0044-1801320
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