RSS-Feed abonnieren

DOI: 10.1055/s-0044-1800895
An In-Depth Examination of Phytochemicals and Medicinal Uses on Morus alba
Authors
Funding None.

Abstract
Morus alba, commonly known as white mulberry, is a plant renowned for its diverse range of bioactive compounds that confer numerous health benefits. This review explores the plant's antioxidant, anti-inflammatory, anticancer, cardiovascular, neuroprotective, hepatoprotective, and antimicrobial properties. The antioxidant effects, primarily attributed to flavonoids, phenolic acids, and terpenoids, help mitigate oxidative stress and protect against various diseases. The anti-inflammatory properties reduce chronic inflammation, while the anticancer compounds induce apoptosis and inhibit tumor growth. Morus alba's cardiovascular benefits include improved endothelial function and lipid metabolism. Its neuroprotective effects protect the brain from oxidative damage and neuroinflammation, supporting cognitive function. The hepatoprotective activity enhances liver health and prevents damage from toxins. Additionally, the plant's antimicrobial properties make it effective against a broad spectrum of pathogens. Overall, Morus alba holds significant potential as a natural therapeutic agent, with applications in both traditional and modern medicines.
Keywords
Morus alba - white mulberry - antioxidant properties - anti-inflammatory effects - anticancer potential - cardiovascular healthCRediT Authorship Contribution Statement
Roshan Kumar Dubey, Satyam Shukla, and Prashant Shukla: data curation and writing-review & editing.
Publikationsverlauf
Eingereicht: 20. August 2024
Angenommen: 28. September 2024
Artikel online veröffentlicht:
30. Dezember 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Jeong JY, Liu Q, Kim SB. et al. Characterization of melanogenesis inhibitory constituents of Morus alba leaves and optimization of extraction conditions using response surface methodology. Molecules 2015; 20 (05) 8730-8741
- 2 Lee SH, Choi SY, Kim H. et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 2002; 25 (08) 1045-1048
- 3 Lee S, Kim DH, Lee JH. et al. Involvement of histaminergic system in the anxiolytic-like activities of Morus alba leaves in mice. Biol Pharm Bull 2013; 36 (11) 1692-1699
- 4 Lee MR, Kim JE, Choi JY. et al. Anti-obesity effect in high-fat-diet-induced obese C57BL/6 mice: study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris . Exp Ther Med 2019; 17 (03) 2185-2193
- 5 Lee YJ, Choi DH, Kim EJ. et al. Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet. Am J Chin Med 2011; 39 (01) 39-52
- 6 Lim HJ, Jin HG, Woo ER. et al. The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation. J Ethnopharmacol 2013; 149 (01) 169-175
- 7 Lim HS, Ha H, Lee H. et al. Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC Complement Altern Med 2014; 14: 139
- 8 Kim ES, Park SJ, Lee EJ. et al. Purification and characterization of Moran 20K from Morus alba . Arch Pharm Res 1999; 22 (01) 9-12
- 9 Łochyńska M, Oleszak G. Multi-use of the white mulberry (Morus alba L.). Ecol Quest 2013; 15 (01) 91
- 10 Lu HP, Jia YN, Peng YL. et al. Oxyresveratrol, a stilbene compound from Morus alba L. twig extract active against Trichophyton rubrum . Phytother Res 2017; 31 (12) 1842-1848
- 11 Ma X, Iwanaka N, Masuda S. et al. Morus alba leaf extract stimulates 5′-AMP-activated protein kinase in isolated rat skeletal muscle. J Ethnopharmacol 2009; 122 (01) 54-59
- 12 Mahmoud MY. Natural antioxidants effect of mulberry fruits (Morus nigra and Morus alba L.) on lipids profile and oxidative stress in hypercholestrolemic rats. Pak J Nutr 2013; 12 (07) 665-672
- 13 Hong Y, Kim MY, Yoon M. The anti-angiogenic herbal extracts Ob-X from Morus alba, Melissa officinalis, and Artemisia capillaris suppresses adipogenesis in 3T3-L1 adipocytes. Pharm Biol 2011; 49 (08) 775-783
- 14 Habeeb N. Fractionation and screening of Morus alba L. leaf extracts and bioassay for antidiabetic activity in the selected animal model. Mysuru, Karnataka, India: University of Mysore; 2014
- 15 Mahmoud AM, Abd El-Twab SM, Abdel-Reheim ES. Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism. Eur J Nutr 2017; 56 (04) 1671-1684
- 16 Marx TK, Glávits R, Endres JR. et al. A 28-day repeated dose toxicological study of an aqueous extract of Morus alba L. Int J Toxicol 2016; 35 (06) 683-691
- 17 Ali Memon A, Memon N, Luthria DL. et al. Phenolic acids profiling and antioxidant potential of mulberry (Morus laevigata W., Morus nigra L., Morus alba L.) leaves and fruits grown in Pakistan. Pol J Food Nutr Sci 2010; 60 (01) 25-32
- 18 Metwally FM, Rashad H, Mahmoud AA. Morus alba L. diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet. Physiol Behav 2019; 201: 1-11
- 19 Nematbakhsh M, Hajhashemi V, Ghannadi A. et al. Protective effects of the Morus alba L. leaf extracts on cisplatin-induced nephrotoxicity in rat. Res Pharm Sci 2013; 8 (02) 71-77
- 20 Niidome T, Takahashi K, Goto Y. et al. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport 2007; 18 (08) 813-816
- 21 Nomura T, Fukai T, Katayanagi M. Studies on the constituents of the cultivated mulberry tree. III. Isolation of four new flavones, kuwanon A, B, C and oxydihydromorusin from the root bark of Morus alba L. Chem Pharm Bull (Tokyo) 1978; 26 (05) 1453-1458
- 22 Nomura T, Fukai T, Hano Y. et al. Constituents of cultivated mulberry tree. Planta Med 1983; 47 (03) 151-156
- 23 Mohamed NE, Ashour SE. Role of ethanolic extract of Morus alba leaves on some biochemical and hematological alterations in irradiated male rats. Int J Radiat Biol 2018; 94 (04) 374-384
- 24 Mohammadi J, Naik PR. The histopathologic effects of Morus alba leaf extract on the pancreas of diabetic rats. Turk J Biol 2012; 36: 211-216
- 25 Mucimapura S, Wattanathorn J, Thongrong S. et al. Morus alba enhanced functional recovery after sciatic nerve crush injury. Am J Agric Biol Sci 2010; 5 (03) 294-300
- 26 Nade VS, Kawale LA, Yadav AV. Protective effect of Morus alba leaves on haloperidol-induced orofacial dyskinesia and oxidative stress. Pharm Biol 2010; 48 (01) 17-22
- 27 Nade V, Kawale L, Bhangale S. et al. Cardioprotective and antihypertensive potential of Morus alba L. in isoproterenol-induced myocardial infarction and renal artery ligation-induced hypertension. J Nat Rem 2013; 13: 54-67
- 28 Naowaboot J, Pannangpetch P, Kukongviriyapan V. et al. Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats. Nutr Res 2009; 29 (08) 602-608
- 29 Naowaratwattana W, De-Eknamkul W, De Mejia EG. Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity. J Med Food 2010; 13 (05) 1045-1056
- 30 Natić MM, Dabić DČ, Papetti A. et al. Analysis and characterisation of phytochemicals in mulberry (Morus alba L.) fruits grown in Vojvodina, North Serbia. Food Chem 2015; 171: 128-136
- 31 Nazari M, Hajizadeh MR, Mahmoodi M. et al. The regulatory impacts of Morus alba leaf extract on some enzymes involved in glucose metabolism pathways in diabetic rat liver. Clin Lab 2013; 59 (5–6): 497-504