RSS-Feed abonnieren

DOI: 10.1055/s-0044-1793952
Assessing Pesticide Exposure and Regulatory Challenges in Malaysia: A Review of Population Monitoring, Food Residue, and Environmental Contamination
Funding and Sponsorship This work was supported by a Universiti Sains Malaysia, Short-Term Grant with Project No: 304/CIPPT/6315592.

Abstract
Pesticide applications do not always stay confined to their target. Human exposure to pesticides can lead to various health effects, such as cancer, reproductive toxicity, and neurodegenerative disorders. For that reason, stringent regulations govern pesticide registration and application before they enter the market. This objective of this article is to review studies conducted in Malaysia related to human biomonitoring and pesticide residue monitoring in the environment and food with the aim to explore the extent and pathway of pesticide exposure among the population, which indirectly allows us to examine the effectiveness of pesticide regulatory systems. Articles published from 2010 until 2024 from ScienceDirect, Scopus, and Google Scholar were explored. In Malaysia, biomonitoring of pesticide is conducted sporadically by independent researchers and does not provide a comprehensive understanding of the population's exposure through various routes of exposures. Additionally, the effectiveness of environmental regulatory measures remains unclear because of lack of monitoring data available publicly for interpretation. Moreover, dietary exposure assessments of pesticide residues in food are conducted randomly in Malaysia. This approach contrasts with other countries where the Total Diet Studies comprehensively evaluate the entire population's exposure to pesticide residues through dietary pathways. In summary, there is a need for a more comprehensive and systematic study of Malaysia's pesticide regulatory system specifically through biological, environmental, and food monitoring. Understanding the effectiveness of current regulations in controlling pesticide exposure is vital not only for public health but also for overall environmental well-being of the nation.
Compliance with Ethical Principles
No ethical approval is required for review-type article.
Authors' Contributions
All authors contributed to collecting the data, writing the article, reviewing, and approving the final article.
Publikationsverlauf
Artikel online veröffentlicht:
27. Dezember 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Mekonen S, Belete B, Melak F, Ambelu A. Determination of pesticide residues in the serum of flower farm workers: a growing occupational hazards in low income countries. Toxicol Rep 2023; 10: 293-300
- 2 Galán-Madruga D, Cárdenas-Escudero J, Broomandi P. et al. Evaluating urban indoor and outdoor PM10-bound organochlorine pesticides. Air quality status and health impact. Build Environ 2023; 228: 109818
- 3 Hyland C, Spivak M, Sheppard L. et al. Urinary glyphosate concentrations among pregnant participants in a randomized, crossover trial of organic and conventional diets. Environ Health Perspect 2023; 131 (07) 77005
- 4 Ganaie MI, Jan I, Mayer AN. et al. Health risk assessment of pesticide residues in drinking water of Upper Jhelum Region in Kashmir Valley-India by GC-MS/MS. Int J Anal Chem 2023; 2023: 6802782
- 5 Department of Statistics Malaysia. Minister of Economy. Economic performance by state, 2022. Minister of Economy Department of Statistics Malaysia; . Published June 27, 2023. Accessed November 24, 2023 at: https://www.dosm.gov.my/portal-main/release-content/gross-domestic-product-gdp-by-state -
- 6 Holliday Jr MW, Li Q, Bustamante EG. et al. Potential mechanisms involved in chronic kidney disease of unclear etiology. Clin J Am Soc Nephrol 2022; 17 (09) 1293-1304
- 7 Pesticide Act. 1974 (Malaysia). Accessed June 1, 2024 at: https://lom.agc.gov.my/act-detail.php?act=149&lang=BI&date=15-03-2023#timeline
- 8 Angerer J, Ewers U, Wilhelm M. Human biomonitoring: state of the art. Int J Hyg Environ Health 2007; 210 (3–4): 201-228
- 9 Kapka-Skrzypczak L, Cyranka M, Skrzypczak M, Kruszewski M. Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. Ann Agric Environ Med 2011; 18 (02) 294-303
- 10 Jung SK, Choi W, Kim SY. et al. Profile of environmental chemicals in the Korean population-results of the Korean National Environmental Health Survey (KoNEHS) Cycle 3, 2015-2017. Int J Environ Res Public Health 2022; 19 (02) 626
- 11 Govarts E, Gilles L, Rodriguez Martin L. et al. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021). Int J Hyg Environ Health 2023; 249: 114119
- 12 Cathey AL, Nguyen VK, Colacino JA, Woodruff TJ, Reynolds P, Aung MT. Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses. J Expo Sci Environ Epidemiol 2023; 33 (05) 687-698
- 13 Occupational Safety and Health (Use and Standard of Exposure Chemical Hazardous to Health) Regulations. 2000 (USECHH Regulations). Accessed June 1, 2024 at: https://www.dosh.gov.my/index.php/legislation/eregulations/regulations-under-occupational-safety-and-health-act-1994-act-514/522-pua-131-2000-1/file
- 14 Department of Occupational Safety and Health Ministry of Human Resources Malaysia. Guidelines on Medical Surveillance; 2001 . Accessed June 1, 2024 at: https://www.dosh.gov.my/images/dmdocuments/glx/gl_medic_surv_2001.pdf
- 15 Kamaruzaman NA, Leong YH, Jaafar MH. et al. Epidemiology and risk factors of pesticide poisoning in Malaysia: a retrospective analysis by the National Poison Centre (NPC) from 2006 to 2015. BMJ Open 2020; 10 (06) e036048
- 16 Vahter M, Gochfeld M, Casati B. et al. Implications of gender differences for human health risk assessment and toxicology. Environ Res 2007; 104 (01) 70-84
- 17 Dahiri B, Martín-Reina J, Carbonero-Aguilar P, Aguilera-Velázquez JR, Bautista J, Moreno I. Impact of pesticide exposure among rural and urban female population. An overview. Int J Environ Res Public Health 2021; 18 (18) 9907
- 18 How V, Singh S, Thinh DQ. et al. Association of blood cholinesterase with sexual differences in metabolic health risks among villagers from pesticide-treated farming villages. Journal of Ecophysiology and Occupational Health. 2020; 20 (1 & 2): 6-12
- 19 Hossain F, Ali O, D'Souza UJA, Naing DK. Effects of pesticide use on semen quality among farmers in rural areas of Sabah, Malaysia. J Occup Health 2010; 52 (06) 353-360
- 20 Th TI, Zain SM, Juahir H, Yusoff MK, Manaf LA. Organophosphate exposure: a preliminary assessment on the use of pesticide intensity score to evaluate exposure among fruit growers. Environ Asia 2010; 3 (03) 204-216
- 21 Hod R, Aizuddin AN, Shah SA. et al. Chlorpyrifos blood level and exposure symptoms among paddy farmers in Sabak Bernam, Malaysia. International Journal of Public Health Research 2011; 1 (01) 1-6
- 22 Baharuddin MRB, Sahid IB, Noor MABM, Sulaiman N, Othman F. Pesticide risk assessment: a study on inhalation and dermal exposure to 2,4-D and paraquat among Malaysian paddy farmers. J Environ Sci Health B 2011; 46 (07) 600-607
- 23 Vivien H, Hashim Z, Ismail P, Said SM, Omar D, Tamrin SBM. Biological monitoring of genotoxicity to organophosphate pesticide exposure among rice farmers: Exposure-effect continuum study. J Occup Health Epidemiol 2013; 2 (01) 27-36
- 24 Abdul Hamid Z, Mohd Zulkifly MF, Hamid A. et al. The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia. Genes Environ 2016; 38 (01) 7
- 25 How V, Hashim Z, Ismail P, Md Said S, Omar D, Bahri Mohd Tamrin S. Exploring cancer development in adulthood: cholinesterase depression and genotoxic effect from chronic exposure to organophosphate pesticides among rural farm children. J Agromedicine 2014; 19 (01) 35-43
- 26 How V, Hashim Z, Ismail P, Omar D, Said SM, Tamrin SB. Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates. Arch Environ Occup Health 2015; 70 (02) 102-109
- 27 Hashim Z, Baguma D. Environmental exposure of organophosphate pesticides mixtures and neurodevelopment of primary school children in Tanjung Karang, Malaysia. Asia Pacific Environ Occup Health J 2015; 1 (01) 44-53
- 28 Samsuddin N, Rampal KG, Ismail NH, Abdullah NZ, Nasreen HE. Pesticide exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia. Am J Hypertens 2016; 29 (02) 226-233
- 29 Sutris JM, How V, Sumeri SA. et al. Genotoxicity following organophosphate pesticides exposure among orang asli children living in an agricultural island in Kuala Langat, Selangor, Malaysia. Int J Occup Environ Med 2016; 7 (01) 42-51
- 30 L NN. Hashim Z. M NH, et al. Organophosphate pesticide mixture exposure: the relationship with the motor coordination of children from paddy farming area in Tanjung Karang, Malaysia. Malaysian Journal of Public Health Medicine 2017; ; Special Volume (01) 115-122
- 31 Sidek Ahmad BZN, Harding AH, Kromhout H. et al. Urinary pesticide metabolite levels among farm workers in Malaysia: pilot results from the impress study. BMJ 2021; A4: 1-A4
- 32 Yusof MZ, Cherrie JW, Samsuddin N, Semple S. Mosquito control workers in Malaysia: is lifetime occupational pesticide exposure associated with poorer neurobehavioral performance?. Ann Work Expo Health 2022; 66 (08) 1044-1055
- 33 Rudzi SK, Ho YB, Tan ESS, Jalaludin J, Ismail P. Exposure to airborne pesticides and its residue in blood serum of paddy farmers in Malaysia. Int J Environ Res Public Health 2022; 19 (11) 6806
- 34 Deziel NC, Friesen MC, Hoppin JA, Hines CJ, Thomas K, Freeman LE. A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas. Environ Health Perspect 2015; 123 (06) 515-524
- 35 Vida P, Moretto A. Pesticide exposure pathways among children of agricultural workers. Warasan Satharanasuk Sat 2007; 15 (04) 289-299
- 36 Food Act. 1983 (Malaysia). Accessed June 1, 2024 at: https://lom.agc.gov.my/act-detail.php?act=281&lang=BI&date=01-04-2012#timeline
- 37 Mohammad N, Abidin EZ, How V, Praveena SM, Hashim Z. Pesticide management approach towards protecting the safety and health of farmers in Southeast Asia. Rev Environ Health 2018; 33 (02) 123-134
- 38 Pesticide Board Malaysia. Guidelines on residue data requirements for pesticide registration. 2012 . June 1, 2024 at: https://www.doa.gov.my/doa/resources/aktiviti_sumber/sumber_awam/maklumat_racun_perosak/pendaftaran_rmp/garis_panduan_data_sisa_baki_rmp.pdf
- 39 Food Standards Australia New Zealand. 25th Australian Total Diet Study. 2019 . Accessed June 1, 2024 at: https://www.foodstandards.gov.au/sites/default/files/2023-11/25th-ATDS.pdf
- 40 Food and Agriculture Organization of the United Nations. FAO Pesticide Residue Monitoring Project for Association of South East Asian Nations (ASEAN) Countries: Situation Assessment. 2020 . Accessed June 1, 2024 at: https://openknowledge.fao.org/server/api/core/bitstreams/db358203-27eb-4c57-a124-5a68178b7397/content
- 41 Sabere ASM, Zakaria Z, Ismail BS. Comparison of the level of organochlorine residues in paddy crops from two different cultivation practices. Sains Malays 2013; 42 (11) 1581-1584
- 42 Abdulra'uf LB, Tan GH. Chemometric approach to the optimization of HS-SPME/GC-MS for the determination of multiclass pesticide residues in fruits and vegetables. Food Chem 2015; 177: 267-273
- 43 Zainudin BH, Salleh S, Mohamed R, Yap KC, Muhamad H. Development, validation and determination of multiclass pesticide residues in cocoa beans using gas chromatography and liquid chromatography tandem mass spectrometry. Food Chem 2015; 172: 585-595
- 44 Farina Y, Abdullah MP, Bibi N, Khalik WM. Determination of pesticide residues in leafy vegetables at parts per billion levels by a chemometric study using GC-ECD in Cameron Highlands, Malaysia. Food Chem 2017; 224: 55-61
- 45 Zainudin BH, Salleh S. Method development, optimization and validation of matrix hydration effect on pesticide residues in cocoa beans using modified QuEChERS method and Gas Chromatography tandem Mass Spectrometry. Food Anal Methods 2017; 10 (12) 3874-3885
- 46 Farina Y, Munawar N, Abdullah MP, Yaqoob M, Nabi A. Fate, distribution, and bioconcentration of pesticides impact on the organic farms of Cameron Highlands, Malaysia. Environ Monit Assess 2018; 190 (07) 386
- 47 Sapahin HA, Makahleh A, Saad B. Determination of organophosphorus pesticide residues in vegetables using solid phase micro-extraction coupled with Gas Chromatography–Flame Photometric detector. Arab J Chem 2019; 12 (08) 1934-1944
- 48 Munawar N, Farina Y, Yaqoob M. et al. Distribution of pesticides in different commonly grown vegetables of Cameron Highlands, Pahang, Malaysia. Sains Malays 2021; 50 (10) 2937-2944
- 49 Jayaraj R, Megha P, Sreedev P. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment. Interdiscip Toxicol 2016; 9 (3–4): 90-100
- 50 Jiang S. Overview of Pesticide Managment in Malaysia. Agrochemical Regulatory News & Database. Published 2017. Accessed June 1, 2024 at: https://agrochemical.chemlinked.com/agropedia/overview-pesticide-managment-malaysia
- 51 Zaidon SZ, Ho YB, Hashim Z. et al. Pesticides contamination and analytical methods of determination in environmental matrices in malaysia and their potential human health effects-a review. Malaysian J Medicine Health Sciences. 2018; 14 (SP1): 2636-9346
- 52 Islam MA, Amin SMN, Rahman MA. et al. Chronic effects of organic pesticides on the aquatic environment and human health: a review. Environ Nanotechnol Monit Manag 2022; 18: 100740
- 53 Zaidon SZ, Ho YB, Hamsan H, Hashim Z, Saari N, Praveena SM. Improved QuEChERS and solid phase extraction for multi-residue analysis of pesticides in paddy soil and water using ultra-high performance liquid chromatography tandem mass spectrometry. Microchem J 2019; 145: 614-621
- 54 Bzour M, Zuki FM, Mispan MS, Jodeh S, Abdel-Latif M. Determination of the leaching potential and residues activity of imidazolinone herbicide in clearfield rice soil using high-performance liquid chromatography. Bull Environ Contam Toxicol 2019; 103 (02) 348-353
- 55 Ismail NAH, Wee SY, Haron DEM, Kamarulzaman NH, Aris AZ. Occurrence of endocrine disrupting compounds in mariculture sediment of Pulau Kukup, Johor, Malaysia. Mar Pollut Bull 2020; 150: 110735
- 56 Marsin FM, Wan Ibrahim WA, Nodeh HR, Sanagi MM. New magnetic oil palm fiber activated carbon-reinforced polypyrrole solid phase extraction combined with gas chromatography-electron capture detection for determination of organochlorine pesticides in water samples. J Chromatogr A 2020; 1612: 460638
- 57 Mohamed AH, Yahaya N, Mohamad S. et al. Synthesis of oil palm empty fruit bunch-based magnetic-carboxymethyl cellulose nanofiber composite for magnetic solid-phase extraction of organophosphorus pesticides in environmental water samples. Microchem J 2022; 183: 108045
- 58 Osman BE, Khalik WMAWM. Data on organochlorine concentration levels in soil of lowland paddy field, Kelantan, Malaysia. Data Brief 2018; 20: 999-1003
- 59 Elfikrie N, Ho YB, Zaidon SZ, Juahir H, Tan ESS. Occurrence of pesticides in surface water, pesticides removal efficiency in drinking water treatment plant and potential health risk to consumers in Tengi River Basin, Malaysia. Sci Total Environ 2020; 712: 136540
- 60 Yang J, Ching YC, Kadokami K. Occurrence and exposure risk assessment of organic micropollutants in indoor dust from Malaysia. Chemosphere 2022; 287 (Pt 3): 132340
- 61 Shopee Mobile Malaysia SB. “chlorpyrifos - Prices and Promotions - Jun 2024 | Shopee Malaysia.”. Accessed June 10, 2024 at: https://shopee.com.my/search?keyword=chlorpyrifos