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CC BY 4.0 · European Journal of General Dentistry 2025; 14(02): 171-177
DOI: 10.1055/s-0044-1792027
Original Article

Assessment of the Prospective Protection of Quercetin on Irradiated Submandibular Salivary Gland in Mice

Nadia A. Radi 
1   Department of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt
,
Doaa A. Habba 
1   Department of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt
2   Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Najran University, Saudi Arabia
,
Seham I. Hallool 
3   Department of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt
,
Hanaa M. Abd Elsamia 
4   Department of Oral and Dental Pathology, Faculty of Oral and Maxillofacial Surgery, Zagazig University, Zagazig, Egypt
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Abstract

Objectives This study aimed to assess the prospective protection of quercetin on irradiated submandibular salivary gland in mice histologically and immunohistochemically.

Material and Methods Four groups of male mice were included in the study. Group included 10 mice that will not be subjected to gamma radiation, group included 10 mice that will receive quercetin 50 mg/kg body weight (BW) for 30 days, group included 10 irradiated mice that will receive a dose of only 15 Gy, and group IV included 10 irradiated mice that will be given quercetin 50 mg/kg BW for 30 days prior to radiotherapy.

Results The analysis of variance (ANOVA) test revealed that the difference between all groups was extremely statistically significant (p < 0.000). Turkey's post hoc test revealed that there were no statistically significant differences between groups I and II but both groups showed statistically significant differences with groups III and IV. Also, there were statistically significant differences between groups III and IV.

Conclusion Quercetin possesses the ability to protect against radiation-induced cellular damage and maintain tissue integrity, so it holds promise as a protective agent for salivary glands against radiation-induced damage. Quercetin has promising potential therapeutic benefits for individuals undergoing radiation therapy.

Keywords

PCNA - quercetin - ROS

* This study was performed at the Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.




Publication History

Article published online:
22 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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