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CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0044-1791942
Case Report

Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature

Authors

  • Lamia Parveen

    1   Department of Dentistry,Burdwan Medical College (WBUHS),Bardhaman, West Bengal, India

  • Sudeshna Bagchi 

    2   Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, India

  • Rudra Prasad Chatterjee

    2   Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, India

  • Abdul Mahmud

    2   Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, India

  • Sangeeta Sinha

    2   Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, India
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Abstract

Granulocytic sarcoma (GS) is a rare extramedullary malignant tumor composed of immature granulocytes, including myeloblasts, promyelocytes, and myelocytes. In most cases, these are associated with persisting blood dyscrasias such as acute myeloid leukemia and chronic myeloid leukemia. To date, 32 cases of GS involving orofacial region have been reported in the English literature. Out of these, only a few presented without any systemic complications. This case reports an unusual occurrence of GS without any associated leukemia involving the mandible of a 29-year-old male patient. Hematoxylin and eosin–stained sections revealed the presence of numerous rounds to ovoid myeloblasts with a multilobated, vesicular nucleus and a prominent nucleolus. The cells stained positive for Cluster of Differentiation 68, lysozyme, and myeloperoxidase. He later underwent chemotherapy but succumbed in the interim period of chemotherapy. We hereby report a unique case of GS of mandible in an apparently healthy individual who deteriorated rapidly; an early and accurate diagnosis of which could have been life-saving.

Keywords

granulocytic sarcoma - mandible - MPO - chemotherapy

Authors' Contribution

L.P. and R.P.C. contributed to the conceptualization. L.P., S.B., R.P.C., and A.M. contributed to the design and definition of intellectual content. L.P., S.B., A.M., and S.S. contributed to the literature search. All authors contributed to the data acquisition and manuscript editing. L.P., S.B., and S.S. contributed to the manuscript preparation. L.P., S.B., and R.P.C. contributed to the manuscript review. L.P. is the guarantor.


If the Manuscript Was Presented as Part at a Conference/Convention/Meeting

Nil.


Declaration of the Patient Consent Form

Consent was taken and the document was attached separately.


Source(s) of Support in the Form of Grants, Equipment, Drugs

Nil.




Publication History

Article published online:
24 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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