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CC BY 4.0 · Int Arch Otorhinolaryngol 2025; 29(01): s00441791731
DOI: 10.1055/s-0044-1791731
Original Research

Plasmatic Levels of Cytokines and Quality of Life among Elderly Individuals with Dizziness

Gislaine da Silva Moreira 
1   Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)/Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
,
Luciana Lozza de Moraes Marchiori 
2   Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
3   Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
4   Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
,
Daiane Soares de Almeida Ciquinato 
3   Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
4   Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
,
Glória de Moraes Marchiori 
2   Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
3   Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
,
Licia Sayuri Tanaka Okamura 
3   Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
,
Braulio Henrique Magnani Branco 
2   Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
3   Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
4   Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
,
Regina Célia Poli-Frederico 
1   Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)/Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
5   Molecular Biology Laboratory, Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
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Funding The authors declare that they did not receive financial support from agencies in the public, private or non-profit sectors to conduct the present study.
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Abstract

Introduction Few studies have investigated the relationship between cytokines and dizziness in elderly individuals.

Objective To assess the levels of inflammatory biomarkers and their relationship with quality of life (QoL) among elderly individuals with dizziness.

Methods We conducted a cross-sectional study with 103 participants (90 women and 13 men) who were assessed through the Visual Analogue Scale (VAS) and the Dizziness Handicap Inventory (DHI). The plasma levels of cytokines were measured through the cytometric bead array (CBA) method. Cross-tabulations with the Chi-squared test were used to verify sample homogeneity, and parametric tests were used to analyze the data.

Results Out of the total sample of 103 individuals, dizziness was reported by 40 women and 5 men. A difference between the groups with and without dizziness was observed regarding the levels of interleukin 4 (IL-4; p = 0.011): the group without dizziness presented a higher mean level (2.1 ± 2.8 pg/mL) when compared to the group that presented dizziness (1.0 ± 1.7 pg/mL). Another difference was found between the DHI classifications and the plasma levels of tumor necrosis factor alpha (TNF-α;) p = 0.015): the groups without any losses in QoL presented lower TNF-α levels (1.4 pg/mL) compared to the group that presented moderate QoL loss (6.3 pg/mL).

Conclusion Dizziness affects the functional, physical and emotional dimensions of QoL and plays a role in the decrease in the levels of IL-4 and in the presence of fullness and tinnitus. Higher VAS scores are related to dizziness in the elderly. Moreover, the increased levels of TNF-α were associated to light-to-moderate losses in QoL among elderly patients with dizziness.

Keywords

aging - quality of life - biomarkers - dizziness


Publikationsverlauf

Eingereicht: 06. Oktober 2023

Angenommen: 21. August 2024

Artikel online veröffentlicht:
22. Januar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Gislaine da Silva Moreira, Luciana Lozza de Moraes Marchiori, Daiane Soares de Almeida Ciquinato, Glória de Moraes Marchiori, Licia Sayuri Tanaka Okamura, Braulio Henrique Magnani Branco, Regina Célia Poli-Frederico. Plasmatic Levels of Cytokines and Quality of Life among Elderly Individuals with Dizziness. Int Arch Otorhinolaryngol 2025; 29: s00441791731.
DOI: 10.1055/s-0044-1791731