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DOI: 10.1055/s-0044-1790217
Analysis of Synovial Fluid Metabolic Profile in Patients with Knee Osteoarthritis Using Spectroscopic Magnetic Resonance Metabolomics
Artikel in mehreren Sprachen: português | EnglishFinancial Support The authors declare that they did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study.
Abstract
Objective The present study aimed to evaluate the metabolic profile of synovial fluid in patients with knee osteoarthritis (KOA) and its correlation with clinical data.
Materials and Methods We collected synovial fluid samples from the knees of 50 subjects with KOA undergoing total knee arthroplasty from October 2019 to December 2020. For each patient, we evaluated the clinical data from the medical record, the radiographic osteoarthritis grade, and the preoperative fasting blood glucose levels. The samples underwent metabolomic analysis by 1H magnetic resonance spectroscopy, and we compared the spectra using multivariate and univariate analyses.
Results Most patients were female (66%). The subjects had an average age of 67.96 ± 7.08 years old and an average body mass index (BMI) of 32.51 ± 5.25 kg/m2. Clinical and metabolic evaluations revealed that 88% of patients were hypertensive and presented higher levels of valine, arginine, and citrate than non-hypertensive subjects.
Conclusion Metabolomic analysis of synovial fluid cannot classify osteoarthritis patients per their clinical characteristics.
Work carried out at the Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad, Rio de Janeiro, RJ, Brazil.
Publikationsverlauf
Eingereicht: 06. Dezember 2023
Angenommen: 23. Juni 2024
Artikel online veröffentlicht:
21. Dezember 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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