Platelet Pathophysiology: Unexpected New Research Directions

Alan D. Michelson; Andrew L. Frelinger III; Robin L. Haynes; Hannah C. Kinney; Thomas Gremmel

doi:10.1055/s-0044-1787663

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2024; 50(08): 1187-1190
DOI: 10.1055/s-0044-1787663

Historical Commentary

Platelet Pathophysiology: Unexpected New Research Directions

Alan D. Michelson

¹Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts

,

Andrew L. Frelinger III

¹Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts

,

Robin L. Haynes

²Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts

,

Hannah C. Kinney

²Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts

,

Thomas Gremmel

³Department of Internal Medicine I, Cardiology and Intensive Care Medicine, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria

⁴Institute of Cardiovascular Pharmacotherapy and Interventional Cardiology, Karl Landsteiner Society, St. Pölten, Austria

⁵Karl Landsteiner University of Health Sciences, Krems, Austria

› Author Affiliations

Abstract

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References

References
1 Gremmel T, Frelinger III AL, Michelson AD. Platelet physiology. Semin Thromb Hemost 2016; 42 (03) 191-204
2 Michelson AD, Cattaneo M, Frelinger AL, Newman PJ. eds. Platelets. 4th ed.. Elsevier; 2019
3 Koupenova M, Livada AC, Morrell CN. Platelet and megakaryocyte roles in innate and adaptive immunity. Circ Res 2022; 130 (02) 288-308
4 Karakas D, Ni H. Unveiling platelets as immune regulatory cells. Circ Res 2024; 134 (08) 987-989
5 Battinelli EM. PEARing into gestational thrombocytopenia. Blood 2024; 143 (15) 1439-1441
6 Sciaudone A, Corkrey H, Humphries F, Koupenova M. Platelets and SARS-CoV-2 during COVID-19: immunity, thrombosis, and beyond. Circ Res 2023; 132 (10) 1272-1289
7 Hofer BS, Brusilovskaya K, Simbrunner B. et al. Decreased platelet activation predicts hepatic decompensation and mortality in patients with cirrhosis. Hepatology 2023; (e-pub ahead of print)
8 Gremmel T, Michelson AD, Frelinger III AL, Bhatt DL. Novel aspects of antiplatelet therapy in cardiovascular disease. Res Pract Thromb Haemost 2018; 2 (03) 439-449
9 Tscharre M, Michelson AD, Gremmel T. Novel antiplatelet agents in cardiovascular disease. J Cardiovasc Pharmacol Ther 2020; 25 (03) 191-200
10 Billiald P, Slater A, Welin M. et al. Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Adv 2023; 7 (07) 1258-1268
11 Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr Pathol 1991; 11 (05) 677-684
12 Goldstein RD, Blair PS, Sens MA. et al; 3rd International Congress on Sudden Infant and Child Death. Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: recommendations from The 3rd International Congress on Sudden Infant and Child Death. Forensic Sci Med Pathol 2019; 15 (04) 622-628
13 Centers for Disease Control and Prevention. Sudden Unexpected Infant Death and Sudden Infant Death Syndrome. 2023 Accessed April 12, 2023 at: https://www.cdc.gov/sids/data.htm
14 Matthews TJ, MacDorman MF, Thoma ME. Infant mortality statistics from the 2013 period linked birth/infant death data set. Natl Vital Stat Rep 2015; 64 (09) 1-30
15 Filiano JJ, Kinney HC. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol Neonate 1994; 65 (3-4): 194-197
16 Panigrahy A, Filiano J, Sleeper LA. et al. Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. J Neuropathol Exp Neurol 2000; 59 (05) 377-384
17 Kinney HC, Randall LL, Sleeper LA. et al. Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome. J Neuropathol Exp Neurol 2003; 62 (11) 1178-1191
18 Paterson DS, Trachtenberg FL, Thompson EG. et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 2006; 296 (17) 2124-2132
19 Kinney HC, Richerson GB, Dymecki SM, Darnall RA, Nattie EE. The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol 2009; 4: 517-550
20 Broadbelt KG, Rivera KD, Paterson DS. et al. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Mol Cell Proteomics 2012; 11 (01) M111.009530
21 Kinney HC, Haynes RL. The serotonin brainstem hypothesis for the sudden infant death syndrome. J Neuropathol Exp Neurol 2019; 78 (09) 765-779
22 Chen JJ, Li Z, Pan H. et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: abnormal intestinal motility and the expression of cation transporters. J Neurosci 2001; 21 (16) 6348-6361
23 Gershon MD. Review article: serotonin receptors and transporters – roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 2004; 20 (Suppl. 07) 3-14
24 Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132 (01) 397-414
25 Anderson GM, Feibel FC, Cohen DJ. Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 1987; 40 (11) 1063-1070
26 Bellido I, Delange L, Gomez-Luque A. The platelet of the patients with ischemic cardiopathy and cardiac valve disease showed a reduction of 8OH-DPAT binding sites. Thromb Res 2008; 121 (04) 555-565
27 Martini C, Trincavelli ML, Tuscano D. et al. Serotonin-mediated phosphorylation of extracellular regulated kinases in platelets of patients with panic disorder versus controls. Neurochem Int 2004; 44 (08) 627-639
28 Nagatomo T, Rashid M, Abul Muntasir H, Komiyama T. Functions of 5-HT2A receptor and its antagonists in the cardiovascular system. Pharmacol Ther 2004; 104 (01) 59-81
29 Kinney HC, Cryan JB, Haynes RL. et al. Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability. Acta Neuropathol 2015; 129 (01) 65-80
30 Cummings KJ, Leiter JC, Trachtenberg FL. et al. Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis. J Neuropathol Exp Neurol 2024; 83 (03) 144-160
31 Haynes RL, Frelinger III AL, Giles EK. et al. High serum serotonin in sudden infant death syndrome. Proc Natl Acad Sci U S A 2017; 114 (29) 7695-7700
32 Frelinger III AL, Haynes RL, Goldstein RD. et al. Dysregulation of platelet serotonin, 14-3-3 and GPIX in sudden infant death syndrome. Sci Rep 2024; 14 (01) 11092
33 Thomsen H, Krisch B. The postmortem activation status of platelets. Int J Legal Med 1994; 107 (03) 111-117
34 Ramachandran PS, Okaty BW, Riehs M. et al. Multiomic analysis of neuroinflammation and occult infection in sudden infant death syndrome. JAMA Neurol 2024; 81 (03) 240-247
35 Thornton P, McColl BW, Greenhalgh A, Denes A, Allan SM, Rothwell NJ. Platelet interleukin-1alpha drives cerebrovascular inflammation. Blood 2010; 115 (17) 3632-3639
36 Rawish E, Nording H, Münte T, Langer HF. Platelets as mediators of neuroinflammation and thrombosis. Front Immunol 2020; 11: 548631
37 Rust C, Malan-Muller S, van den Heuvel LL. et al. Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: a narrative review. J Neuroimmunol 2023; 382: 578155
38 Kopeikina E, Ponomarev ED. The role of platelets in the stimulation of neuronal synaptic plasticity, electric activity, and oxidative phosphorylation: possibilities for new therapy of neurodegenerative diseases. Front Cell Neurosci 2021; 15: 680126
39 Kopeikina E, Dukhinova M, Yung AWY. et al. Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress. Prog Neurobiol 2020; 188: 101783
40 Kinney HC, Broadbelt KG, Haynes RL, Rognum IJ, Paterson DS. The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis. J Chem Neuroanat 2011; 41 (04) 182-199