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CC BY 4.0 · World J Nucl Med 2024; 23(03): 212-216
DOI: 10.1055/s-0044-1787537
Case Report

Early Hyperprogression of Rhabdomyosarcoma Detected by 18F-FDG PET/CT Three Weeks after CAR-T Treatment

Autoren

  • Shenrui Guo‡   *

    1   Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  • Zhen Tan‡   *

    2   Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  • Wenbin Guan

    3   Department of Pathology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  • Yafu Yin 

    1   Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Abstract

Chimeric antigen receptor T-cell (CAR-T) treatment has been widely used in the treatment of hematological malignancies, and its application has been gradually expanded to the research and treatment of solid tumors. However, unconventional types of response may occur after CAR-T treatment, such as hyperprogression, resulting in terrible outcomes. Here, we report the case of a 13-year-old adolescent boy with relapsed and refractory rhabdomyosarcoma who developed early hyperprogression 3 weeks after CAR-T treatment (target: B7H3 and CD171), which was detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT). The patient eventually underwent amputation. Attention should be paid to the possibility of early hyperprogression after CAR-T treatment, and 18F-FDG PET/CT has an absolute advantage in early evaluating treatment response to immunotherapy.

Keywords

18F-FDG PET/CT - hyperprogression - rhabdomyosarcoma - CAR-T treatment - pediatric

Authors' Contributions

S.G. participated in data analysis and interpretation, and wrote the original draft of the manuscript text. Z.T. provided the clinical data, and revised the manuscript. W.G. provided the pathological images and related figure legend. Y.Y. contributed to conceptualization, participated in the interpretation, and revised the manuscript. S.G. and Z.T. contributed equally to this work and should be considered co-first authors.


* These authors contributed equally to this work.




Publikationsverlauf

Artikel online veröffentlicht:
20. Juni 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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