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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(02): e149-e154
DOI: 10.1055/s-0044-1787010
Original Article

Chemical Constituents of the Marine Traditional Chinese Medicine of Pegasus laternarius Cuvier (Hai-E Yu)

Autor*innen

  • Shuqian Sun   #

    1   School of Chemistry and Chemical Engineering, University of Jinan, Jinan, People's Republic of China

  • Zhen Gao   #

    2   Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, People's Republic of China
    3   State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China

  • Mengxue Wang

    2   Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, People's Republic of China

  • Sha Chen

    2   Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, People's Republic of China

  • Wenjuan Guo

    1   School of Chemistry and Chemical Engineering, University of Jinan, Jinan, People's Republic of China

  • Xuwen Li

    2   Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, People's Republic of China
    3   State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China

Funding This work was supported by the National Key Research and Development Program of China (Grant No. 2021YFF0502400), the Shanghai Rising-Star Program (Grant No. 20QA1411100), “Youth Innovation Promotion Association” of the Chinese Academy of Sciences (Grant No. Y202065), Youth Fund from Natural Science Foundation of Shandong Province (Grant No. ZR2023QD162), and the Shandong Science and Technology Major Project of Innovation and Entrepreneurship Community with Antibody-drug (Grant No. E321020).
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Graphical Abstract

Abstract

Pegasus laternarius Cuvier (Hai-E Yu) is a marine traditional Chinese medicine that has been used to treat cancers and reduce inflammation. Previous chemical investigations have only revealed the occurrence of high levels of protein, fatty acids, and a large number of steroids, thus more active compounds in P. laternarius still need to be further discovered. The present study aims to search for new bioactive constituents of P. laternarius with cytotoxic effects and nitric oxide (NO) inhibitory activities. In this work, 16 pure compounds from the ethyl acetate fraction of Pegasus laternarius Cuvier were successively obtained by various chromatographic techniques, and the structure of the isolates was elucidated by spectroscopic analyses. The isolated and identified compounds included one 2H-1,2,3-triazole-4-carboxylate derivative (1), two oxadiazines (2, 3), two amino acids (4, 5), three nucleosides (6–8), three steroids (9–11), and five others (12–16). All the obtained compounds were evaluated for their antitumor activity on A549 and HCT-116 cell lines along with their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. The triazole compound 1 was found to exhibit moderate cytotoxicity against two human cell lines (A549 and HCT-116) with IC50 values of 44.5 and 32.9 μmol/L, respectively. The steroid compound 10 inhibited NO production with IC50 values lower than 50 μmol/L. Consequently, this study provides insight into the cytotoxic and NO inhibitory activities of the marine traditional Chinese medicines in Hai-E-Yu.

Keywords

marine traditional Chinese medicine - Pegasus laternarius Cuvier - cytotoxicity - anti-inflammatory

Ethical Approval

None declared.


# These authors contributed equally to this work.


Supplementary Material



Publikationsverlauf

Eingereicht: 15. November 2023

Angenommen: 24. April 2024

Artikel online veröffentlicht:
30. Mai 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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